1-(2,3-Dideoxy-3-fluoropentofuranosyl)pyrimidine-2,4(1H,3H)-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-(2,3-Dideoxy-3-fluoropentofuranosyl)pyrimidine-2,4(1H,3H)-dione
• 英文别名: 1-[4-fluoro-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• 化学式: C₉H₁₁FN₂O₄
• mdl: MFCD04037836
• 分子量: 230.19
• InChiKey: BKIUEHLYJFLWPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.555
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• ANTIVIRAL NUCLEOSIDES
  申请人：Kumar Rakesh

  公开号：US20100130440A1

  公开（公告）日：2010-05-27

  Disclosed are nucleosides which are useful in diagnosing and treating viral infections, for example, infections caused by hepatitis B virus (HBV), and herpes viruses including Epstein Barr virus.

  本发明涉及一种核苷，其在诊断和治疗病毒感染中有用，例如由乙型肝炎病毒（HBV）和包括Epstein-Barr病毒在内的疱疹病毒引起的感染。
• Antiviral nucleosides
  申请人：Kumar, Rakesh

  公开号：EP2322534A1

  公开（公告）日：2011-05-18

  Disclosed are nucleosides which are useful in diagnosing and treating viral infections, for example, infections caused by hepatitis B virus (HBV), and herpes viruses including Epstein Barr virus

  所公开的核苷类药物可用于诊断和治疗病毒感染，例如由乙型肝炎病毒（HBV）和疱疹病毒（包括 Epstein Barr 病毒）引起的感染。
• MODIFIED RNAI AGENTS
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：EP2880162B1

  公开（公告）日：2017-07-05
• Cell culture medium
  申请人：Genetix Limited

  公开号：EP1818392B1

  公开（公告）日：2010-08-25
• CELL CULTURE MEDIUM
  申请人：Bramke Irene

  公开号：US20110104754A1

  公开（公告）日：2011-05-05

  We describe a method of growing an animal cell in a culture medium, in which the culture medium comprises an elevated concentration of a thymidine family member, in which the growth or viability of the animal cell is increased as a result of the elevated concentration of the thymidine family member in the cell culture medium. Preferably, the cell culture medium comprises a semi-solid medium, which is a serum free or chemically defined medium.