[5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxyphosphinic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: [5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxyphosphinic acid
• 化学式: C₁₀H₁₅N₂O₆P
• 分子量: 290.21
• InChiKey: ZTSAWAJOEAZLAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] POLY-MORPHOLINO OLIGONUCLEOTIDE GAPMERS<br/>[FR] GAPMÈRES DE POLY-MORPHOLINO OLIGONUCLÉOTIDES
  申请人：[en]EISAI R&D MANAGEMENT CO., LTD.

  公开号：WO2022125987A1

  公开（公告）日：2022-06-16

  Gapmers or pharmaceutically acceptable salt of the gapmers and methods of making the gapmers are provided. The gapmers include a gap region that contains deoxyribonucleosides linked to each other by phosphorothioate bonds, a 5' wing region positioned at the 5' end of the gap region that contains morpholino monomers linked to each other by phosphorodiamidate bonds, and a 3' wing region positioned at the 3' end of the gap region that contains morpholino monomers linked to each other by phosphorodiamidate bonds. Antisense oligonucleotides are also provided. These antisense oligonucleotides are useful in the preparation of gapmers for inhibition of Tau mRNA transcription.