(2S)-4-(3-hydroxyphenyl)-2-methylbutanal | 479495-46-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (2S)-4-(3-hydroxyphenyl)-2-methylbutanal
• CAS: 479495-46-0
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: ZMJLFYLNLOTJRY-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2S)-4-(3-hydroxyphenyl)-2-methylbutanal 在 四氮唑 、 双氧水 、 丙酸 作用下， 以 甲苯 为溶剂， 反应 2.0h， 生成 (5R,6S)-6-methyl-3-phenyl-2,4-dioxa-3lambda5-phosphatricyclo[7.3.1.05,13]trideca-1(12),9(13),10-triene 3-oxide
  参考文献：
  名称：

  Progress towards the decalin portion of (+)-compactin

  摘要：

  A new approach to a chiral tetrahydronaphthalene precursor for the decalin portion of (+)-compactin is disclosed. The strategy utilises two key steps: a boron-catalysed diastereoselective annulation reaction to a key dioxaborin ester which was then transformed to a dioxaphosphinin-2-oxide for use in a diastereoselective S,,2 reaction affording the two substituents at C-1 and C-2 with the cis stereochemistry required in a (+)-compactin skeleton. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00570-0
• 作为产物：
  描述：

  3-(叔丁基二甲基硅氧基)苯甲醛 在 palladium on activated charcoal 正丁基锂 、 四丁基氟化铵 、 氢气 作用下， 生成 (2S)-4-(3-hydroxyphenyl)-2-methylbutanal
  参考文献：
  名称：

  Progress towards the decalin portion of (+)-compactin

  摘要：

  A new approach to a chiral tetrahydronaphthalene precursor for the decalin portion of (+)-compactin is disclosed. The strategy utilises two key steps: a boron-catalysed diastereoselective annulation reaction to a key dioxaborin ester which was then transformed to a dioxaphosphinin-2-oxide for use in a diastereoselective S,,2 reaction affording the two substituents at C-1 and C-2 with the cis stereochemistry required in a (+)-compactin skeleton. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00570-0