2-Ethoxyallylmethylamin | 41455-28-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Ethoxyallylmethylamin
• 英文别名: 2-ethoxy-N-methylprop-2-en-1-amine
• CAS: 41455-28-1
• 化学式: C₆H₁₃NO
• mdl: MFCD19222717
• 分子量: 115.175
• InChiKey: LRAHCIWXWUDMPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  α-Ethoxy-N-methylacrylamid 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 2-Ethoxyallylmethylamin
  参考文献：
  名称：

  1,3,4,5-四氢苯并[ c，d ]吲哚和相关化合物。第四部分 麦角酸的合成尝试

  摘要：

  尝试设计通过甲基N-丙酮基-N {1,3,4,5-tetrahydro-5由3,4-二氢苯并[ c，d ]吲哚-5（1 H）-一（I）合成麦角酸的尝试-氧代-1-（对甲苯磺酰基）苯并[ c，d ]吲哚-4-基}氨基甲酸酯（23）由于难以将后者环化成四环酮（4）而失败。

  DOI：

  10.1039/p19730000760

文献信息

• [EN] PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE<br/>[FR] PTÉRIDINONES EN TANT QU'INHIBITEURS DE POLO-LIKE KINASE
  申请人：ELAN PHARM INC

  公开号：WO2011079114A1

  公开（公告）日：2011-06-30

  The present invention provides compounds having a structure according to Formula (I) or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6, are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

  本发明提供了具有如下结构式(I)的化合物或其盐或溶剂化物，其中环A、X、R1、R2、R3、R4、R5和R6的定义如本文所述。本发明还提供了包括本发明化合物的药物组合物以及制造和使用本发明化合物和组合物的方法，例如，在治疗和预防各种疾病，如帕金森病。
• Conversion of tryptophan into ß-carboline derivatives
  申请人：LEK Pharmaceuticals d.d.

  公开号：EP2107059A1

  公开（公告）日：2009-10-07

  The invention belongs in the field of organic chemistry and relates to a new shortened Pictet-Spengler type reaction for preparing isomerically pure β-carboline compounds useful for the synthesis of tadalafil.

  这项发明属于有机化学领域，涉及一种用于制备同分异构纯度β-咔啉化合物的新型缩短的Pictet-Spengler型反应，该化合物对于制备他达拉非（tadalafil）非常有用。
• [EN] CONVERSION OF TRYPTOPHAN INTO ß-CARBOLINE DERIVATIVES<br/>[FR] CONVERSION DU TRYPTOPHANE EN DÉRIVÉS DE ?-CARBOLINE
  申请人：LEK PHARMACEUTICALS

  公开号：WO2009121791A1

  公开（公告）日：2009-10-08

  The invention belongs in the field of organic chemistry and relates to a new shortened Pictet- Spengler type reaction for preparing isomerically pure ß-carboline compounds useful for the synthesis of tadalafil.

  该发明属于有机化学领域，涉及一种新的缩短的Pictet-Spengler型反应，用于制备同分异构纯的ß-咔啉化合物，用于合成万艾可。
• CREATINE ESTER PRONUTRIENT COMPOUNDS AND FORMULATIONS
  申请人：Vennerstrom L. Jonathan

  公开号：US20070203076A1

  公开（公告）日：2007-08-30

  The present invention describes a method for providing creatine to an animal, which includes receiving a creatine ester by the animal. The creatine ester is suitable for being modified by the animal to form creatine.
• [EN] PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE<br/>[FR] PTÉRIDINONES EN TANT QU'INHIBITEURS DE POLO-LIKE KINASE
  申请人：ELAN PHARM INC

  公开号：WO2011079118A1

  公开（公告）日：2011-06-30

  The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, E1, E2, R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.