9-甲基-7,9-二氢-8H-嘌呤-8-酮 | 39188-96-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 9-甲基-7,9-二氢-8H-嘌呤-8-酮
• 英文名称: 7,8-dihydro-8-oxo-9-methylpurine
• 英文别名: 9-methyl-7,9-dihydro-purin-8-one；9-Methyl-7,9-dihydro-purin-8-on；9-Methylpurin-8-on；9-methyl-7H-purin-8(9H)-one；9-methyl-7H-purin-8-one
• CAS: 39188-96-0
• 化学式: C₆H₆N₄O
• 分子量: 150.14
• InChiKey: PIVJPLYRMYPIAF-UHFFFAOYSA-N

物化性质

• 密度：
  1.383±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  58.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  8-(methylthio)-9-methylpurine 在 potassium amide 作用下， 以 氨 为溶剂， 反应 0.75h， 以50%的产率得到9-甲基-9H-嘌呤-8-胺
  参考文献：
  名称：

  Pyrimidines. Part 96. Anion formation and ring opening of 9-substituted purines in liquid ammonia containing potassium amide

  摘要：

  DOI：

  10.1021/jo00154a021

文献信息

• SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME
  申请人：BlinkBio, Inc.

  公开号：US20170202970A1

  公开（公告）日：2017-07-20

  Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.

  本文描述了基于硅的共轭物，能够将一个或多个有效载荷基团传递到靶细胞或组织。考虑到的共轭物可能包括一个硅-杂原子核心，一个或多个可选的催化基团，一个定位基团，允许共轭物在靶细胞或组织内积累，一个或多个有效载荷基团（例如，治疗剂或成像剂），以及与硅-杂原子核心共价结合的两个或更多个不干扰基团。
• Imidazolone phenylalanine derivatives
  申请人：Stappenbeck Frank

  公开号：US20070037804A1

  公开（公告）日：2007-02-15

  Disclosed are compounds of the formula: and the pharmaceutically acceptable salts thereof wherein the variables A, n, R 5 , R 21 —R 24 and Q are defined herein. These compounds bind VLA-4. Certain of these compound also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

  本发明涉及下述公式的化合物及其药学上可接受的盐，其中变量A、n、R5、R21-R24和Q如本文所定义。这些化合物与VLA-4结合。其中某些化合物还抑制白细胞粘附，特别是通过VLA-4介导的白细胞粘附。这些化合物在哺乳动物患者（例如人类）的炎症性疾病治疗中有用，如哮喘、阿尔茨海默病、动脉粥样硬化、艾滋病痴呆、糖尿病、炎症性肠病、类风湿性关节炎、组织移植、肿瘤转移和心肌缺血。这些化合物还可以用于治疗多发性硬化等炎症性脑部疾病。
• FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS
  申请人：Taniguchi Takahiko

  公开号：US20130172328A1

  公开（公告）日：2013-07-04

  The present invention provides a compound which has the effect of PDE inhibition, and which is useful as an agent for preventing or treating schizophrenia or so on represented by the formula (I):

  本发明提供了一种化合物，具有PDE抑制作用，可用作预防或治疗精神分裂症等药物，其化学式为（I）：
• FUSED HETEROCYCLIC COMPOUNDS
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20130303553A1

  公开（公告）日：2013-11-14

  The present invention provides a compound which has the effect of PDE inhibition, and which is useful as an agent for preventing or treating schizophrenia. The compound is represented by the formula (I): wherein the symbols are defined in the specification.

  本发明提供了一种具有PDE抑制作用的化合物，可用作预防或治疗精神分裂症的药剂。该化合物由式(I)表示：其中符号在说明书中定义。
• [EN] OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF<br/>[FR] COMPOSITIONS D'OLIGONUCLÉOTIDES ET PROCÉDÉS ASSOCIÉS
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2022099159A1

  公开（公告）日：2022-05-12

  Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.

  除其他事项外，本公开提供寡核苷酸及其组合物。在某些实施例中，提供的寡核苷酸及其组合物对腺苷修饰有用。在某些实施例中，本公开提供了治疗各种需要腺苷修饰的疾病、疾病或病症的方法。