6-isopropylthieno[2,3-b]pyridine-2-carboxylic acid | 398137-21-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 6-isopropylthieno[2,3-b]pyridine-2-carboxylic acid
• 英文别名: 6-propan-2-ylthieno[2,3-b]pyridine-2-carboxylic acid
• CAS: 398137-21-8
• 化学式: C₁₁H₁₁NO₂S
• 分子量: 221.28
• InChiKey: AYWJXSPSUHCKFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  78.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-amino-2-neopentyloxybenzonitrile 、 6-isopropylthieno[2,3-b]pyridine-2-carboxylic acid 以the title compound (0.6 g) was obtained的产率得到N-(3-cyano-4-neopentyloxyphenyl)-6-isopropylthieno[2,3-b]pyridine-2-carboxamide
  参考文献：
  名称：

  Fused bicyclic amide compounds and medicinal use thereof

  摘要：

  以下是通式（I）所代表的化合物，其中环A为苯、环己烷、吡啶、哌啶、其衍生物、咪唑、其衍生物等；环B代表苯、环己烷、吡咯或其衍生物、呋喃、噻吩等；R1、R2和R3分别代表氢、烷基、卤素、羟基、烷氧基等；W代表氢、烷基或羟基羧基烷基；X代表卤素、氰基、硝基等；X'代表氢、卤素等；Y代表烷基、羟基烷基、羟基羧基烷基、氨基烷基等；以及这些化合物的盐和含有这些化合物的药物。由于具有抑制活化淋巴细胞增殖的优异效果，这些化合物可用作各种自身免疫性疾病的预防或治疗药物。

  公开号：

  US07112594B2

文献信息

• AMIDE DERIVATIVE AND USE THEREOF
  申请人：Ushio Hiroyuki

  公开号：US20130211075A1

  公开（公告）日：2013-08-15

  The present invention relates to a novel amide derivative. More specifically, the present invention provides a medicinal agent useful as a prophylactic or therapeutic agent for diseases, which relies on the production of cytokines from T cells, and which comprises an amide derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or the pharmacologically acceptable salt as an active ingredient. Provided is an amide derivative represented by general formula (I) [wherein each symbol is as defined in the description] or a pharmacologically acceptable salt thereof, or a solvate of the derivative or the pharmacologically acceptable salt.

  本发明涉及一种新型酰胺衍生物。更具体地说，本发明提供了一种药用剂，可用作依赖于T细胞产生细胞因子的疾病的预防或治疗剂，该药用剂包括酰胺衍生物或其药理学上可接受的盐或该衍生物或药理学上可接受的盐的溶剂的溶剂作为活性成分。提供的是由通式(I)所表示的酰胺衍生物[其中每个符号如描述中所定义]或其药理学上可接受的盐，或该衍生物或药理学上可接受的盐的溶剂。
• FUSED BICYCLIC AMIDE COMPOUNDS AND MEDICINAL USE THEREOF
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1310488A1

  公开（公告）日：2003-05-14

  The present invention provides a compound represented by the formula (I) wherein ring A is benzene, cyclohexane, pyridine, piperidine or a derivative thereof, imidazole or a derivative thereof and the like, ring B is benzene, cyclohexane, pyrrole or a derivative thereof, furan, thiophene and the like, R1, R2 and R3 are each hydrogen, alkyl, halogen, hydroxyl group, alkoxy and the like, W is hydrogen, alkyl or hydroxycarbonylalkyl, X is halogen, cyano, nitro and the like, X' is hydrogen, halogen and the like, and Y is alkyl, hydroxyalkyl, hydroxycarbonylalkyl, aminoalkyl and the like, a salt thereof, and a pharmaceutical agent containing the compound. The compound of the present invention shows a superior inhibitory effect on the proliferation of activated lymphocyte and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.

  本发明提供了一种由式（I）表示的化合物 其中环 A 是苯、环己烷、吡啶、哌啶或其衍生物、咪唑或其衍生物等，环 B 是苯、环己烷、吡咯或其衍生物、呋喃、噻吩等，R1、R2 和 R3 分别是氢、烷基、卤素、羟基、烷氧基等，W 是氢、烷基或羟基羰基烷基，X 是卤素、氰基、硝基等、W为氢、烷基或羟基羰基烷基，X为卤素、氰基、硝基等，X'为氢、卤素等，Y为烷基、羟基烷基、羟基羰基烷基、氨基烷基等，其盐以及含有该化合物的药剂。本发明的化合物对活化淋巴细胞的增殖有很好的抑制作用，可作为预防或治疗各种自身免疫性疾病的药物。
• US7112594B2
  申请人：——

  公开号：US7112594B2

  公开（公告）日：2006-09-26
• US9150555B2
  申请人：——

  公开号：US9150555B2

  公开（公告）日：2015-10-06
• Fused bicyclic amide compounds and medicinal use thereof
  申请人：——

  公开号：US20030203909A1

  公开（公告）日：2003-10-30

  The present invention provides a compound represented by the formula (I) 1 wherein ring A is benzene, cyclohexane, pyridine, piperidine or a derivative thereof, imidazole or a derivative thereof and the like, ring B is benzene, cyclohexane, pyrrole or a derivative thereof, furan, thiophene and the like, R 1 , R 2 and R 3 are each hydrogen, alkyl, halogen, hydroxyl group, alkoxy and the like, W is hydrogen, alkyl or hydroxycarbonylalkyl, X is halogen, cyano, nitro and the like, X′ is hydrogen, halogen and the like, and Y is alkyl, hydroxyalkyl, hydroxycarbonylalkyl, aminoalkyl and the like, a salt thereof, and a pharmaceutical agent containing the compound. The compound of the present invention shows a superior inhibitory effect on the proliferation of activated lymphocyte and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.

  本发明提供了一种由以下化学式（I）1所代表的化合物，其中环A为苯、环己烷、吡啶、哌啶或其衍生物、咪唑或其衍生物等，环B为苯、环己烷、吡咯或其衍生物、呋喃、噻吩等，R1、R2和R3分别为氢、烷基、卤素、羟基、烷氧基等，W为氢、烷基或羟基羰基烷基，X为卤素、氰基、硝基等，X′为氢、卤素等，Y为烷基、羟基烷基、羟基羰基烷基、氨基烷基等，其盐和含有该化合物的药物。本发明的化合物对活化淋巴细胞的增殖具有优越的抑制作用，并可用作各种自身免疫性疾病的预防或治疗剂。