1-(3,4-dimethoxyphenyl)-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: 1-(3,4-dimethoxyphenyl)-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• 化学式: C₂₀H₂₂N₂O₂
• 分子量: 322.4
• InChiKey: RMNZGFZXNFIQQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  46.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME
  申请人：Nogra Pharma Limited

  公开号：US20170158707A1

  公开（公告）日：2017-06-08

  The present invention is generally directed towards compounds capable of binding the aryl hydrocarbon receptor and modulating its activity, methods of treating inflammatory conditions such as Crohn's disease using such compounds, and pharmaceutical compositions comprising such compounds. Also provided are methods of increasing levels of IL-22 in a subject and/or decreasing levels of IFN-γ in a subject.