N-[4-(2-Methylimidazo[1,2-A]pyridin-3-YL)-2-pyrimidinyl]acetamide | 611239-38-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: N-[4-(2-Methylimidazo[1,2-A]pyridin-3-YL)-2-pyrimidinyl]acetamide
• 英文别名: N-[4-(2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]acetamide
• CAS: 611239-38-4
• 化学式: C₁₄H₁₃N₅O
• 分子量: 267.29
• InChiKey: ZCRPPLDDHBLUES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  72.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Antistress drug and medical use thereof
  申请人：Ohmoto Kazuyuki

  公开号：US20070099938A1

  公开（公告）日：2007-05-03

  The compound represented by formula (I) (wherein ringA is cyclic group which may have a substituent(s), Q is alkyl which may have a substituent(s) or cyclic ring which may have a substituent(s), ringD is cyclic ring which may have a substituent(s), W is a single bond or a spacer of which main chain has an atom number of 1-4, Y is a spacer of which main chain has an atom number of 1-4.), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof Since the compounds represented by formula (I), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof have the affinity to MBR, they are useful for the prevention and/or treatment for disease caused by stress.

  化合物的分子式为（I）（其中环A是一个可以有取代基的环状基团，Q是一个可以有取代基或环状基团的烷基，环D是一个可以有取代基的环状基团，W是一个单键或具有1-4个原子数的主链的间隔键，Y是具有1-4个原子数的主链的间隔键），其盐，N-氧化物或溶剂化物，或其前药。由于分子式（I）所代表的化合物，其盐，N-氧化物或溶剂化物，或其前药具有对MBR的亲和力，因此它们对于预防和/或治疗由压力引起的疾病是有用的。
• ANTISTRESS DRUG AND MEDICAL USE THEREOF
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1679309A1

  公开（公告）日：2006-07-12

  The compound represented by formula (I) (wherein ringA is cyclic group which may have a substituent(s), Q is alkyl which may have a substituent(s) or cyclic ring which may have a substituent(s), ringD is cyclic ring which may have a substituent(s), W is a single bond or a spacer of which main chain has an atom number of 1-4, Y is a spacer of which main chain has an atom number of 1-4.), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof Since the compounds represented by formula (I), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof have the affinity to MBR, they are useful for the prevention and/or treatment for disease caused by stress.

  式 (I) 所代表的化合物 (其中，环 A 为可带取代基的环状基团，Q 为可带取代基的烷基或可带取代基的环状环，环 D 为可带取代基的环状环，W 为单键或主链原子序数为 1-4 的间隔键，Y 为主链原子序数为 1-4 的间隔键)、其盐、其 N-氧化物或其溶液或其原药。由于式 (I) 所代表的化合物、其盐、其 N-氧化物或其溶解物或其原药具有与 MBR 的亲和力，因此可用于预防和/或治疗由压力引起的疾病。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• ADVANCED DRUG DEVELOPMENT AND MANUFACTURING
  申请人：Los Alamos National Security, LLC

  公开号：EP2084519A2

  公开（公告）日：2009-08-05
• X-RAY FLUORESCENCE ANALYSIS METHOD
  申请人：Los Alamos National Security, LLC

  公开号：EP2084519B1

  公开（公告）日：2012-08-01