methyl (2E)-3-[1-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydro[1]benzothieno[2,3-c]pyridin-1-yl]acrylate | 1259948-25-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: methyl (2E)-3-[1-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydro[1]benzothieno[2,3-c]pyridin-1-yl]acrylate
• CAS: 1259948-25-8
• 化学式: C₂₃H₂₃NO₃S
• 分子量: 393.507
• InChiKey: WEGYFPPIYGRQEU-WYMLVPIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.37
• 重原子数：
  28.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  38.77
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  1-(4-methoxyphenyl)-2-methyl-3,4-dihydro-1H-[1]benzothiolo[2,3-c]pyridine 、 丙炔酸甲酯 以 二氯甲烷 为溶剂， 反应 480.0h， 以68%的产率得到methyl 6-(4-methoxyphenyl)-3-methyl-1,2,3,6-tetrahydro[1]benzothieno[3,2-d]azocine-5-carboxylate
  参考文献：
  名称：

  Tandem transformations of tetrahydrobenzothieno[2,3-c]pyridines in the presence of activated alkynes

  摘要：

  The reactivity of some new tetrahydrothienopyridines towards activated alkynes was investigated. A novel cascade cleavage-spiroannulation process, leading to the formation of previously unreported derivatives of 1'H-spiro[1-benzothiophene-3,4'-pyridine] was discovered and studied. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.09.098

文献信息

• Tandem transformations of tetrahydrobenzothieno[2,3-c]pyridines in the presence of activated alkynes
  作者：Leonid G. Voskressensky、Svetlana A. Kovaleva、Tatiana N. Borisova、Anna V. Listratova、Alexandr B. Eresko、Valery S. Tolkunov、Sergey V. Tolkunov、Alexey V. Varlamov

  DOI：10.1016/j.tet.2010.09.098

  日期：2010.11

  The reactivity of some new tetrahydrothienopyridines towards activated alkynes was investigated. A novel cascade cleavage-spiroannulation process, leading to the formation of previously unreported derivatives of 1'H-spiro[1-benzothiophene-3,4'-pyridine] was discovered and studied. (C) 2010 Elsevier Ltd. All rights reserved.