3-methylphenyl(2-naphthyl)methanol | 944669-15-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-methylphenyl(2-naphthyl)methanol
• 英文别名: (3-Methylphenyl)-naphthalen-2-ylmethanol
• CAS: 944669-15-2
• 化学式: C₁₈H₁₆O
• 分子量: 248.324
• InChiKey: ZNBWNOFQFYVRQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-甲基苯硼酸 、 2-萘甲醛 在 1-(2,6-diisopropylphenyl)-3-(2-(phenylthio)phenyl)-4,5-dihydroimidazolinium chloride 、 bis(η3-allyl-μ-chloropalladium(II)) 、 caesium carbonate 作用下， 以 水 为溶剂， 以85%的产率得到3-methylphenyl(2-naphthyl)methanol
  参考文献：
  名称：

  Palladium-imidazolinium carbene-catalyzed arylation of aldehydes with arylboronic acids in water

  摘要：

  The catalytic arylation of aldehydes with arylboronic acids in only water was found to be achieved using the palladium/thioether-imidazolinium chloride system in good to excellent yields. This catalytic process showed high tolerance for a broad range of substrates, giving a variety of carbinol derivatives with 2.0-3.0 mol % of the catalyst. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.06.049

文献信息

• Palladium-imidazolinium carbene-catalyzed arylation of aldehydes with arylboronic acids in water
  作者：Masami Kuriyama、Natsuki Ishiyama、Rumiko Shimazawa、Osamu Onomura

  DOI：10.1016/j.tet.2010.06.049

  日期：2010.8

  The catalytic arylation of aldehydes with arylboronic acids in only water was found to be achieved using the palladium/thioether-imidazolinium chloride system in good to excellent yields. This catalytic process showed high tolerance for a broad range of substrates, giving a variety of carbinol derivatives with 2.0-3.0 mol % of the catalyst. (C) 2010 Elsevier Ltd. All rights reserved.