N-[6-(1,3-dithian-2-yl)-4-oxo-3H-pteridin-2-yl]-2,2-dimethylpropanamide | 1031890-56-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: N-[6-(1,3-dithian-2-yl)-4-oxo-3H-pteridin-2-yl]-2,2-dimethylpropanamide
• CAS: 1031890-56-8
• 化学式: C₁₅H₁₉N₅O₂S₂
• 分子量: 365.48
• InChiKey: JBDQLMQLLLXOEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  147
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1,3-丙二硫醇 、 2-Pivaloylamino-6-formylpteridin-4-one 在 molybdenium(VI) dioxodichloride 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以68%的产率得到N-[6-(1,3-dithian-2-yl)-4-oxo-3H-pteridin-2-yl]-2,2-dimethylpropanamide
  参考文献：
  名称：

  Molybdenum pentachloride (MoCl5) or molybdenum dichloride dioxide (MoO2Cl2): advanced catalysts for thioacetalization of heterocyclic, aromatic and aliphatic compounds

  摘要：

  A new, convenient and mild method for thioacetalization of heterocyclic, aromatic and aliphatic compounds catalyzed by MoCl(5) or MoO(2)Cl(2) is described. This novel method is important for the synthesis of the difficult to prepare heterocyclic thioacetals such as the pterin thioacetals and it offers significant advantages such as high conversion, short reaction times and simplicity in operation. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.03.048

文献信息

• Molybdenum pentachloride (MoCl5) or molybdenum dichloride dioxide (MoO2Cl2): advanced catalysts for thioacetalization of heterocyclic, aromatic and aliphatic compounds
  作者：Shyamaprosad Goswami、Annada C. Maity

  DOI：10.1016/j.tetlet.2008.03.048

  日期：2008.5

  A new, convenient and mild method for thioacetalization of heterocyclic, aromatic and aliphatic compounds catalyzed by MoCl(5) or MoO(2)Cl(2) is described. This novel method is important for the synthesis of the difficult to prepare heterocyclic thioacetals such as the pterin thioacetals and it offers significant advantages such as high conversion, short reaction times and simplicity in operation. (C) 2008 Elsevier Ltd. All rights reserved.