N,N'-dineopentylethylenediamine | 134226-10-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-dineopentylethylenediamine
• 英文别名: N,N'-bis(2,2-dimethylpropyl)ethane-1,2-diamine
• CAS: 134226-10-1
• 化学式: C₁₂H₂₈N₂
• 分子量: 200.368
• InChiKey: OUFNOWUREGICHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-dineopentylethylenediamine 在 三乙胺 、 三氯化磷 作用下， 以 乙醚 、 甲苯 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  P,N-配位叶立德官能化膦 (NYPhos)：用于小亲核试剂选择性单芳基化的配体平台

  摘要：

  报道了一种新的P,N-配位膦配体平台，其特征是带有氨基鏻基团的叶立德取代基。该配体易于合成且高度模块化，可以轻松调整其电子和空间特性以及氮供体强度。这种灵活性使得能够开发出一种温和且高效的方案，用于丙酮、酮、酰胺、氨和胺的选择性单芳基化。

  DOI：

  10.1002/anie.202408947
• 作为产物：
  描述：

  特戊胺 、 1,2-二溴乙烷 以 乙醇 、 水 为溶剂， 反应 1.0h， 以36%的产率得到N,N'-dineopentylethylenediamine
  参考文献：
  名称：

  Ruthenium catalyzed reactions of ethylene glycol with primary amines: steric factors and selectivity control

  摘要：

  The selectivity of reactions of ethylene glycol with primary amines in the presence of RuCl2(PPh3)3 at 120-degrees-C is highly dependent on the steric nature of the amine. Selectivity to di-amination is favored by smaller alkyl groups on the amine while large amines cleanly yield ethanolamines. This contrasts with the results obtained with secondary amines at this temperature, in which ruthenium-triphenylphosphine catalyst systems always favor mono-amination. In the case of sec-butyl amine, where almost equal amounts of mono- and di-aminated product are obtained, the selectivity can be shifted to mono-amination by the addition of excess triphenylphosphine. The steric effects seen in these reactions are consistent with standard steric parameters available from the literature.

  DOI：

  10.1016/0022-328x(91)83143-r

文献信息

• [EN] SELECTIN OR GALECTIN ANTAGONISTS FOR TREATING CYTOKINE RELEASE SYNDROME AND CRS-INDUCED NEUROTOXICITY<br/>[FR] ANTAGONISTES DE LA SÉLECTINE OU DE LA GALECTINE POUR LE TRAITEMENT DU SYNDROME DE LIBÉRATION DE LA CYTOKINE ET DE LA NEUROTOXICITÉ INDUITE PAR LE CRS
  申请人：MAGNANI JOHN L

  公开号：WO2020150263A1

  公开（公告）日：2020-07-23

  Methods and compounds for the treatment and/or prevention of CRS and/or CRS-induced neurotoxicities using at least one selectin antagonist are disclosed. The disclosed methods and compounds use at least one of the disclosed antagonists to target and reduce cytokine expression and/or endothelial activation to treat and/or prevent CRS and/or CRS-related conditions such as CRS-induced neurotoxicities.

  使用至少一种选择素拮抗剂治疗和/或预防CRS和/或CRS诱导的神经毒性的方法和化合物被披露。披露的方法和化合物使用至少一种披露的拮抗剂来靶向和减少细胞因子表达和/或内皮活化，以治疗和/或预防CRS和/或CRS相关症状，如CRS诱导的神经毒性。
• Diaminodicyanoquinones: Fluorescent Dyes with High Dipole Moments and Electron‐Acceptor Properties
  作者：Philipp Rietsch、Felix Witte、Sebastian Sobottka、Gregor Germer、Alexander Krappe、Arne Güttler、Biprajit Sarkar、Beate Paulus、Ute Resch‐Genger、Siegfried Eigler

  DOI：10.1002/anie.201903204

  日期：2019.6.11

  yields, and have therefore been neglected as fluorescent dyes. Here we investigate the fluorescence properties of diaminodicyanoquinones using a combined theoretical and experimental approach and derive molecules with a fluorescence quantum yield exceeding 90 %. The diaminodicyanoquinone core moiety provides chemical versatility and can be integrated into novel molecular architectures with unique photophysical

  荧光染料被应用于各种研究领域，包括太阳能电池和发光设备，以及作为测定和生物成像研究的报告分子。具有高偶极矩的荧光染料为非线性光学和极性灵敏度铺平了道路。氧化还原活性可以改变分子的光物理性质。二氨基二氰基醌衍生物具有高偶极矩，但荧光量子产率低，因此被忽略为荧光染料。在这里，我们使用理论和实验相结合的方法研究二氨基二氰基醌的荧光性质，并得出具有超过90％的荧光量子产率的分子。
• HETEROBIFUNCTIONAL INHIBITORS OF E-SELECTIN AND GALECTIN-3
  申请人：GLYCOMIMETICS, INC.

  公开号：US20200399301A1

  公开（公告）日：2020-12-24

  Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands a disclosed. For example, heterobifunctional inhibitors of E-selectin and galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.
• GALACTOPYRANOSYL-CYCLOHEXYL DERIVATIVES AS E-SELECTIN ANTAGONISTS
  申请人：GLYCOMIMETICS, INC.

  公开号：US20220175808A1

  公开（公告）日：2022-06-09

  Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, E-selectin antagonists are described and pharmaceutical compositions comprising at least one of the same.
• Ruthenium catalyzed reactions of ethylene glycol with primary amines: steric factors and selectivity control
  作者：John A. Marsella

  DOI：10.1016/0022-328x(91)83143-r

  日期：1991.4

  The selectivity of reactions of ethylene glycol with primary amines in the presence of RuCl2(PPh3)3 at 120-degrees-C is highly dependent on the steric nature of the amine. Selectivity to di-amination is favored by smaller alkyl groups on the amine while large amines cleanly yield ethanolamines. This contrasts with the results obtained with secondary amines at this temperature, in which ruthenium-triphenylphosphine catalyst systems always favor mono-amination. In the case of sec-butyl amine, where almost equal amounts of mono- and di-aminated product are obtained, the selectivity can be shifted to mono-amination by the addition of excess triphenylphosphine. The steric effects seen in these reactions are consistent with standard steric parameters available from the literature.