3-cyano-2-[(1-thiophen-2-ylmethanoyl)amino]-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid ethyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 3-cyano-2-[(1-thiophen-2-ylmethanoyl)amino]-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid ethyl ester
• 英文别名: ethyl 3-cyano-2-(thiophene-2-carbonylamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-6-carboxylate
• 化学式: C₁₆H₁₅N₃O₃S₂
• 分子量: 361.445
• InChiKey: HHLQQPDXPOOOLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  139
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER
  申请人：Nycomed GmbH

  公开号：EP1756118B1

  公开（公告）日：2008-05-28
• Tetrahydropyridothiophenes for Use in the Treatment of Cancer
  申请人：Pekari Klaus

  公开号：US20070213360A1

  公开（公告）日：2007-09-13

  Compounds of the formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.
• Tetrahydropyridothiophenes For Use In The Treatment Of Cancer
  申请人：PEKARI Klaus

  公开号：US20090163538A1

  公开（公告）日：2009-06-25

  Compounds of formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.
• US7517986B2
  申请人：——

  公开号：US7517986B2

  公开（公告）日：2009-04-14