6-bromo-3-phenyl-1H-quinazoline-2,4-dithione | 87474-47-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-bromo-3-phenyl-1H-quinazoline-2,4-dithione
• CAS: 87474-47-3
• 化学式: C₁₄H₉BrN₂S₂
• 分子量: 349.275
• InChiKey: DQJMUJVIJWGDFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3,4,6-四乙酰氧基-alpha-D-吡喃葡萄糖溴化物 、 6-bromo-3-phenyl-1H-quinazoline-2,4-dithione 在 氢氧化钾 作用下， 以 水 、 丙酮 为溶剂， 以28%的产率得到Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(6-bromo-3-phenyl-4-thioxo-3,4-dihydro-quinazolin-2-ylsulfanyl)-tetrahydro-pyran-3-yl ester
  参考文献：
  名称：

  Synthesis, Conformational and Configurational Studies of Some New Acetylated Glycosides of 2-Thio-3-aryl-4(3H)-quinazolinones, Their Thiono and 3,1-Benzothiazin-2,4-dithione

  摘要：

  A series of some new acetylated (S) under bar-glycosides of 2-thioxoquinazolin-4-ones, their thiono analogues and 3,1-benzothazin-2,4-dithione derivatives, including a D-glucose and a D-galactose derivatives and a D-xylose, and an L-arabinose derivatives have been synthesized. The conformation and configuration of these carbohydrate derivatives were determined by analysing their H-1 and C-13 NMR chemical shifts and coupling constants. The biological activity of these compounds has been studied.

  DOI：

  10.1080/15257779508010718
• 作为产物：
  描述：

  5-溴靛红酸酐 在 tetraphosphorus decasulfide 作用下， 以 various solvent(s) 为溶剂， 生成 6-bromo-3-phenyl-1H-quinazoline-2,4-dithione
  参考文献：
  名称：

  Leistner, Siegfried; Hentschel, Karin; Wagner, Guenther, Zeitschrift fur Chemie, 1983, vol. 23, # 6, p. 215 - 216

  摘要：

  DOI：

文献信息

• LEISTNER, S.;HONTSCHEL, K.;WAGNER, G., Z. CHEM., 1983, 23, N 6, 215-216
  作者：LEISTNER, S.、HONTSCHEL, K.、WAGNER, G.

  DOI：——

  日期：——
• Leistner, Siegfried; Hentschel, Karin; Wagner, Guenther, Zeitschrift fur Chemie, 1983, vol. 23, # 6, p. 215 - 216
  作者：Leistner, Siegfried、Hentschel, Karin、Wagner, Guenther

  DOI：——

  日期：——
• Synthesis, Conformational and Configurational Studies of Some New Acetylated Glycosides of 2-Thio-3-aryl-4(3H)-quinazolinones, Their Thiono and 3,1-Benzothiazin-2,4-dithione
  作者：Mohamed F. Abdel-Megeed、Mohamed A. Saleh、Youssef L. Aly、Ibrahim M. Abdo

  DOI：10.1080/15257779508010718

  日期：1995.11

  A series of some new acetylated (S) under bar-glycosides of 2-thioxoquinazolin-4-ones, their thiono analogues and 3,1-benzothazin-2,4-dithione derivatives, including a D-glucose and a D-galactose derivatives and a D-xylose, and an L-arabinose derivatives have been synthesized. The conformation and configuration of these carbohydrate derivatives were determined by analysing their H-1 and C-13 NMR chemical shifts and coupling constants. The biological activity of these compounds has been studied.