3,4-bis(4-hydroxyphenyl)-3-octene | 120743-53-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3,4-bis(4-hydroxyphenyl)-3-octene
• CAS: 120743-53-5
• 化学式: C₂₀H₂₄O₂
• 分子量: 296.409
• InChiKey: OGXKGZKRFIIHCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.61
• 重原子数：
  22.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  40.46
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  1,2-bis(4-methoxyphenyl)hexanone 在 氢氧化钾 、 对甲苯磺酸 、 magnesium 作用下， 以 乙二醇 为溶剂， 反应 51.75h， 生成 3,4-bis(4-hydroxyphenyl)-3-octene
  参考文献：
  名称：

  Diethylstilbestrol-linked cytotoxic agents. Synthesis and binding affinity for estrogen receptors

  摘要：

  The syntheses of diethylstilbestrol derivatives with a C4 side chain at the double bond bearing various functional and potentially alkylating groups (9-25, 38-40, 43, 44) as well as the coupling product with daunorubicin (41) are described. Derivatives with free phenolic groups show easy isomerization to (Z)-stilbenes and styrenes, which could be minimized with silyl protecting groups. Estrogen receptor binding is decreased by polar groups such as carboxylic acids (10) as well as sterically demanding substituents.

  DOI：

  10.1021/jm00127a022

文献信息

• Diethylstilbestrol-linked cytotoxic agents. Synthesis and binding affinity for estrogen receptors
  作者：Karsten Krohn、Konrad Kulikowski、Guy Leclercq

  DOI：10.1021/jm00127a022

  日期：1989.7

  The syntheses of diethylstilbestrol derivatives with a C4 side chain at the double bond bearing various functional and potentially alkylating groups (9-25, 38-40, 43, 44) as well as the coupling product with daunorubicin (41) are described. Derivatives with free phenolic groups show easy isomerization to (Z)-stilbenes and styrenes, which could be minimized with silyl protecting groups. Estrogen receptor binding is decreased by polar groups such as carboxylic acids (10) as well as sterically demanding substituents.