N,3-dimethyl-N-phenylquinolin-2-amine | 7505-14-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,3-dimethyl-N-phenylquinolin-2-amine
• CAS: 7505-14-8
• 化学式: C₁₇H₁₆N₂
• 分子量: 248.32
• InChiKey: FODKOPFBMCXKDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Compounds useful for treating AIDS
  申请人：ABIVAX

  公开号：US10017498B2

  公开（公告）日：2018-07-10

  A compound having the following formula or a pharmaceutically acceptable salt thereof: where: R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NR1R2 group, a (C1-C3)fluoroalkoxy group, a —NO2 group, a phenoxy group, or a (C1-C4)alkoxy group, R1 and R2 are independently a hydrogen atom or a (C1-C3)alkyl group, R′ is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, or a (C1-C4)alkoxy group, R″ is a hydrogen atom or a (C1-C4)alkyl group, n is 1, 2, or 3, and n′ is 1 or 2.

  具有下式的化合物或其药学上可接受的盐： 其中 R 独立地代表氢原子、卤素原子、(C1-C3)烷基、-NR1R2 基团、(C1-C3)氟烷氧基、-NO2 基团、苯氧基或 (C1-C4)烷氧基、 R1 和 R2 独立地为氢原子或 (C1-C3) 烷基、 R′ 是氢原子、卤素原子、(C1-C3)烷基或(C1-C4)烷氧基、 R″ 是氢原子或 (C1-C4) 烷基、 n 是 1、2 或 3，以及 n′ 为 1 或 2。
• COMPOUNDS USEFUL FOR TREATING AIDS
  申请人：Tazi Jamal

  公开号：US20120283265A1

  公开（公告）日：2012-11-08

  The present invention relates to compound Formula (I) wherein: Formula (II) means a pyridazine, a pyrimidine or a pyrazine group, R independently represent a hydrogen atom, a halogen atom or a group chosen among a CN group, a hydroxyl group, a COOR 1 group, a (C 1 -C 3 )fluoroalkyl group, a (C 1 -C 3 )fluoroalkoxy group, a NO 2 group, a NR 1 R 2 group, a (C 1 -C 4 )alkoxy group, a phenoxy group and a (C 1 -C 3 )alkyl group, said alkyl being optionally mono-substituted by a hydroxyl group, n is 1, 2 or 3, n is 1 or 2, R is a hydrogen atom, a halogen atom or a group chosen among a (C 1 -C 3 )alkyl group, a hydroxyl group, a COOR 1 group, a NO 2 group, a NR 1 R 2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (C 1 -C 3 )fluoroalkyl group, a (C 1 -C 4 )alkoxy group and a CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C, for use as an agent for preventing, inhibiting or treating AIDS. Some of said compounds are new and also form part of the invention.
• COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES
  申请人：ABIVAX

  公开号：US20160151348A1

  公开（公告）日：2016-06-02

  Methods for preventing or treating retroviral infection not HIV and/or for preventing, inhibiting or treating a disease caused by the retroviral infection include contacting a cell with compound (I) wherein: means a pyridazine, pyrimidine or pyrazine group, R independently represent a hydrogen atom, halogen atom or group chosen among a —CN, hydroxyl, —COOR 1 , (C 1 -C 3 )fluoroalkyl, (C 1 -C 3 )fluoroalkoxy, —NO 2 , —NR 1 R 2 , (C 1 -C 4 )alkoxy, phenoxy and (C 1 -C 3 )alkyl group, the alkyl being optionally mono-substituted by hydroxyl group, n is 1, 2 or 3, n′ is 1 or 2, R′ is a hydrogen atom, halogen atom or group chosen among (C 1 -C 3 )alkyl group, hydroxyl group, —COOR 1 group, —NO 2 group, —NR 1 R 2 group, morpholinyl or morpholino group, N-methylpiperazinyl group, (C 1 -C 3 )fluoroalkyl group, (C 1 -C 4 )alkoxy group and —CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C.
• COMPOUNDS FOR PREVENTING, INHIBITING, OR TREATING CANCER, AIDS AND/OR PREMATURE AGING
  申请人：ABIVAX

  公开号：US20170226095A1

  公开（公告）日：2017-08-10

  The manufacture and use of compounds of formula (Ia) or a pharmaceutically acceptable salt thereof for preventing, inhibiting or treating cancer, AIDS and/or premature aging. The compounds of formula (Ia) being: where: R independently represents a hydrogen atom, a halogen atom, a (C 1 -C 3 )alkyl group, a —CN group, a hydroxyl group, a —COOR 1 group, a (C 1 -C 3 )fluoroalkyl group, a —NO 2 group, a —NR 1 R 2 group, or a (C 1 -C 3 )alkoxy group; R′ is a hydrogen atom, a halogen atom, a (C 1 -C 3 )alkyl group, a —NO 2 group, a (C 1 -C 3 )alkoxy group, or a —NR 1 R 2 group; and R 1 and R 2 are a hydrogen atom or a (C 1 -C 3 ) alkyl group.
• US9145367B2
  申请人：——

  公开号：US9145367B2

  公开（公告）日：2015-09-29