5-Benzyl-3a,6a-dimethyl-4,6-dihydrofuro[3,4-c]pyrrole-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃吡咯
• 英文名称: 5-Benzyl-3a,6a-dimethyl-4,6-dihydrofuro[3,4-c]pyrrole-1,3-dione
• 化学式: C₁₅H₁₇NO₃
• 分子量: 259.3
• InChiKey: CGEZSUAGBOGSIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• TARGETED COMPOSITIONS
  申请人：Arbutus Biopharma Corporation

  公开号：EP3950004A1

  公开（公告）日：2022-02-09

  The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

  本发明提供了某些核酸（如双链 siRNA 分子）以及由靶向分子、双链 siRNA 和任选连接基团组成的共轭物。某些实施方案还提供了制备共轭物的合成方法。这些共轭物可用于将治疗性双链 siRNA 靶向肝脏并治疗包括肝炎（如乙型肝炎和丁型肝炎）在内的肝脏疾病。
• THERAPEUTIC METHODS
  申请人：Genevant Sciences GmbH

  公开号：EP3873530A1

  公开（公告）日：2021-09-08
• [EN] SYNTHETIC PROCESSES AND INTERMEDIATES<br/>[FR] PROCÉDÉS ET INTERMÉDIAIRES DE SYNTHÈSE
  申请人：ARBUTUS BIOPHARMA CORP

  公开号：WO2021127214A1

  公开（公告）日：2021-06-24

  The invention provides synthetic processes and synthetic intermediate compounds that can be used to prepare therapeutic conjugates. The invention also provides methods for treating HBV and/or HDV infection in a human by administering a therapeutic conjugate prepared by the synthetic methods of the invention.