6,7-Dimethoxy-4H-benzo[1,4]oxazine-2,3-dione | 81055-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 6,7-Dimethoxy-4H-benzo[1,4]oxazine-2,3-dione
• 英文别名: 6,7-dimethoxy-4H-1,4-benzoxazine-2,3-dione
• CAS: 81055-29-0
• 化学式: C₁₀H₉NO₅
• 分子量: 223.185
• InChiKey: HIROQYZVZOWXTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  草酰氯 、 2-amino-4,5-dimethoxyphenol 以 甲苯 为溶剂， 反应 2.0h， 生成 6,7-Dimethoxy-4H-benzo[1,4]oxazine-2,3-dione
  参考文献：
  名称：

  [1,4]Benzoxazine-2,3-diones as antiallergic agents

  摘要：

  The synthesis of a series of [1,4]benzoxazine-2,3-diones and a new class of compounds, benzobisoxazinetetrones, is described. These compounds were evaluated for their effect in the rat mast cell (RMC) test passively sensitized in vitro with rat antiovalbumin serum and for their effect in inhibitory passive cutaneous anaphylaxis (PCA) in the rat. Some of these compounds are of the same potency level as disodium cromglycate in the RMC test and some are effective orally in PCA.

  DOI：

  10.1021/jm00379a006

文献信息

• LOEV, B.;JONES, H.;BROWN, R. E.;HUANG, FU-CHIH;KHANDWALA, A.;LEIBOWITZ, M+, J. MED. CHEM., 1985, 28, N 1, 24-27
  作者：LOEV, B.、JONES, H.、BROWN, R. E.、HUANG, FU-CHIH、KHANDWALA, A.、LEIBOWITZ, M+

  DOI：——

  日期：——
• [1,4]Benzoxazine-2,3-diones as antiallergic agents
  作者：Bernard Loev、Howard Jones、Richard E. Brown、Fu Chih Huang、Atul Khandwala、Mitchell J. Leibowitz、Paula Sonnino-Goldman

  DOI：10.1021/jm00379a006

  日期：1985.1

  The synthesis of a series of [1,4]benzoxazine-2,3-diones and a new class of compounds, benzobisoxazinetetrones, is described. These compounds were evaluated for their effect in the rat mast cell (RMC) test passively sensitized in vitro with rat antiovalbumin serum and for their effect in inhibitory passive cutaneous anaphylaxis (PCA) in the rat. Some of these compounds are of the same potency level as disodium cromglycate in the RMC test and some are effective orally in PCA.