naphthalen-2-yl(p-tolyl)methanamine | 1019396-31-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: naphthalen-2-yl(p-tolyl)methanamine
• 英文别名: (4-Methylphenyl)-naphthalen-2-ylmethanamine
• CAS: 1019396-31-6
• 化学式: C₁₈H₁₇N
• 分子量: 247.34
• InChiKey: BNPDEEONZIQSNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-甲基-4-(硝基甲基)苯 在 t-BuXPhos 、 tris-(dibenzylideneacetone)dipalladium(0) 、 potassium carbonate 、 锌 作用下， 以 溶剂黄146 为溶剂， 反应 16.0h， 生成 naphthalen-2-yl(p-tolyl)methanamine
  参考文献：
  名称：

  Palladium-Catalyzed α-Arylation of Aryl Nitromethanes

  摘要：

  Catalytic conditions for the alpha-arylation of aryl nitromethanes have been discovered using parallel microscale experimentation, despite two prior reports of the lack of reactivity of these aryl nitromethane precursors. The method efficiently provides a variety of substituted, isolable diaryl nitromethanes. In addition, it is possible to sequentially append two different aryl groups to nitromethane. Mild oxidation conditions were identified to afford the corresponding benzophenones via the Nef reaction, and reduction conditions were optimized to afford several diaryl methylamines.

  DOI：

  10.1021/acs.orglett.5b02793

文献信息

• METHODS OF PREPARING PRIMARY, SECONDARY AND TERTIARY CARBINAMINE COMPOUNDS IN THE PRESENCE OF AMMONIA
  申请人：Thadani Avinash N.

  公开号：US20100174090A1

  公开（公告）日：2010-07-08

  The present application relates to novel methods for the preparation of primary, secondary and tertiary carbinamine compounds, particularly the preparation of compounds of formulae I, IV and VI, from a carbonyl compound of formula II in the presence of ammonia or an ammonium equivalent of the formula NH 4 + X − , by way of allylation, crotylation, arylation, reductive amination and catalytic hydrogenation.
• METHODS OF PREPARING SECONDARY CARBINAMINE COMPOUNDS WITH BORONIC ACIDS
  申请人：Thadani Avinash N.

  公开号：US20100298572A1

  公开（公告）日：2010-11-25

  The present application relates to novel methods for the preparation of secondary carbinamine compounds, particularly the preparation of secondary carbinamine compounds of the formula Ia, formula Ib or formula IV from aldehydes of the formula II and boronic acids of the formula III or formula V, in the presence of ammonia or an ammonia equivalent of the formula NH 4+X− .
• US8350047B2
  申请人：——

  公开号：US8350047B2

  公开（公告）日：2013-01-08
• US8383859B2
  申请人：——

  公开号：US8383859B2

  公开（公告）日：2013-02-26