alchivemycin A | 1011254-38-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: alchivemycin A
• CAS: 1011254-38-8
• 化学式: C₃₅H₅₃NO₁₀
• 分子量: 647.807
• InChiKey: ZEXKBCGEARGIOX-MPNGMOIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  46.0
• 可旋转键数：
  3.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  172.82
• 氢给体数：
  5.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  alchivemycin A 、 (S)-(+)-alpha-甲氧基苯乙酸 在 4-二甲氨基吡啶 、 N,N'-二异丙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 以1 mg的产率得到
  参考文献：
  名称：

  Alchivemycin A, a Bioactive Polycyclic Polyketide with an Unprecedented Skeleton from Streptomyces sp.

  摘要：

  Alchivemycin A, a novel polycyclic polyketide, was isolated from the culture extract of a plant-derived actinomycete Streptomyces sp. The structure and relative configuration were elucidated by spectroscopic analysis and X-ray crystallography, and the absolute configuration was determined by a H-1 NMR anisotropy method using MPA ester derivatization. The new compound contains an unprecedented heterocyclic ring system, 2H-tetrahydro-4,6-dioxo-1,2-oxazine. Alchivemycin A showed potent antimicrobial activity against Micrococcus luteus and inhibitory effects on tumor cell invasion.

  DOI：

  10.1021/ol1012982

文献信息

• Alchivemycin A, a Bioactive Polycyclic Polyketide with an Unprecedented Skeleton from <i>Streptomyces</i> sp.
  作者：Yasuhiro Igarashi、Youngju Kim、Yasuko In、Toshimasa Ishida、Yukiko Kan、Tsuyoshi Fujita、Takashi Iwashita、Hirokazu Tabata、Hiroyasu Onaka、Tamotsu Furumai

  DOI：10.1021/ol1012982

  日期：2010.8.6

  Alchivemycin A, a novel polycyclic polyketide, was isolated from the culture extract of a plant-derived actinomycete Streptomyces sp. The structure and relative configuration were elucidated by spectroscopic analysis and X-ray crystallography, and the absolute configuration was determined by a H-1 NMR anisotropy method using MPA ester derivatization. The new compound contains an unprecedented heterocyclic ring system, 2H-tetrahydro-4,6-dioxo-1,2-oxazine. Alchivemycin A showed potent antimicrobial activity against Micrococcus luteus and inhibitory effects on tumor cell invasion.