N'-(4-羟基苯基)-N,N-二甲基-甲脒 | 2350-51-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: N'-(4-羟基苯基)-N,N-二甲基-甲脒
• 英文名称: N-(p-Hydroxyphenyl)-N',N'-dimethylformamidin
• 英文别名: Formamidine, N'-(p-hydroxyphenyl)-N,N-dimethyl-；N'-(4-hydroxyphenyl)-N,N-dimethylmethanimidamide
• CAS: 2350-51-8
• 化学式: C₉H₁₂N₂O
• 分子量: 164.207
• InChiKey: YXTSZBNGJXQOIM-UHFFFAOYSA-N

物化性质

• 熔点：
  210-215 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• 海关编码：
  2925290090

反应信息

• 作为反应物：
  描述：

  N'-(4-羟基苯基)-N,N-二甲基-甲脒 、 3,4-二氯氯苄 在 氢氧化钾 作用下， 以 二甲基亚砜 为溶剂， 生成 N'-[4-(3,4-Dichloro-benzyloxy)-phenyl]-N,N-dimethyl-formamidine
  参考文献：
  名称：

  CH563713

  摘要：

  公开号：
• 作为产物：
  描述：

  对氨基苯酚 、 N,N-二甲基甲酰胺二甲基缩醛 以 甲醇 为溶剂， 反应 3.0h， 生成 N'-(4-羟基苯基)-N,N-二甲基-甲脒
  参考文献：
  名称：

  Annovel formamidine linker for use in solid-phase synthesis

  摘要：

  A variety of amidines have been evaluated as linkers for solid-supported synthesis. As a demonstration of its utility, an amidine linker was used to prepare a set of compounds involving amine exchange, oxidation, reduction and ether formation reactions. These compounds were successfully cleaved from the support to generate alpha-substituted, secondary amine derivatives, which were thoroughly characterized by spectroscopic methods. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)01200-8

文献信息

• CH563713
  申请人：——

  公开号：——

  公开（公告）日：——
• Annovel formamidine linker for use in solid-phase synthesis
  作者：Paul S. Furth、Michael S. Reitman、Alan F. Cook

  DOI：10.1016/s0040-4039(97)01200-8

  日期：1997.8

  A variety of amidines have been evaluated as linkers for solid-supported synthesis. As a demonstration of its utility, an amidine linker was used to prepare a set of compounds involving amine exchange, oxidation, reduction and ether formation reactions. These compounds were successfully cleaved from the support to generate alpha-substituted, secondary amine derivatives, which were thoroughly characterized by spectroscopic methods. (C) 1997 Elsevier Science Ltd.