N(2)-乙基鸟嘌呤 | 19545-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: N(2)-乙基鸟嘌呤
• 英文名称: 2-ethylamino-6-hydroxypurine
• 英文别名: 2-(ethylamino)-9H-purin-6-ol；N²-Ethylguanin；2-ethylamino-1,7(9)-dihydro-purin-6-one；N(2)-Ethylguanine；2-(ethylamino)-1,7-dihydropurin-6-one
• CAS: 19545-00-7
• 化学式: C₇H₉N₅O
• 分子量: 179.181
• InChiKey: LFCHIGIKBKLZIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  82.2
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  tert-butyl 2-[(tert-butoxycarbonyl)(ethyl)amino]-6-chloro-9H-purine-9-carboxylate 在 甲酸 、 水 作用下， 反应 2.0h， 以86%的产率得到N(2)-乙基鸟嘌呤
  参考文献：
  名称：

  N 2烷基化鸟嘌呤的便捷合成

  摘要：

  一种改进的N个三步合成2 -烷基化鸟嘌呤选自N开始已经开发2 -Boc保护其用Boc处理2-氨基-6-氯嘌呤2 O，将得到的双Ñ 2，9-保护的衍生物是用卤代烷进行N 2-烷基化，然后水解。该方法的优点包括反应步骤短，操作简单和产率高。

  DOI：

  10.1134/s1070428019060198

文献信息

• Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK)
  申请人：CHEN Han-Min

  公开号：US20140303112A1

  公开（公告）日：2014-10-09

  The present invention relates to a method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK) and the use of the compounds in the prevention or treatment of disease, including pre-diabetes, type 2 diabetes, syndrome X, metabolic syndrome and obesity.

  本发明涉及一种治疗疾病或病情的方法，该疾病或病情容易通过AMPK激活剂和公式化合物得到改善，这些化合物有助于激活AMP激活蛋白激酶（AMPK），并将这些化合物用于预防或治疗疾病，包括糖尿病前期、2型糖尿病、X综合症、代谢综合征和肥胖症。
• PEPTIDE NUCLEIC ACID DERIVATIVES WITH GOOD CELL PENETRATION AND STRONG AFFINITY FOR NUCLEIC ACID
  申请人：Lee Jong-Ook

  公开号：US20110178031A1

  公开（公告）日：2011-07-21

  The present invention provides a novel class of peptide nucleic acid derivatives, which show good cell penetration and strong binding affinity for nucleic acid.

  本发明提供了一类新型的肽核酸衍生物，它们具有良好的细胞穿透性和对核酸的强结合亲和力。
• Shape Memory Polymers
  申请人：Anthamatten Mitchell L.

  公开号：US20110251364A1

  公开（公告）日：2011-10-13

  The present disclosure relates to Shape Memory Polymers (SMP's) comprising function groups that allow the polymers to be elastically deformed, utilized in the elastically deformed state, and subsequently returned to the original polymorphic shape.

  本公开涉及具有功能基团的形状记忆聚合物（SMP），这些功能基团使聚合物能够弹性变形，在弹性变形状态下使用，并随后返回到原始的多形态形状。
• O2-Arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1- (2-carboxylato)pyrrolidin-1-yl diazen-1-ium-1,2-diolates
  申请人：The United States Government Office of Technoloy Transfer

  公开号：EP1439187A1

  公开（公告）日：2004-07-21

  Diazeniumdiolates, wherein the N1 position is substituted by an inorganic or organic moiety and the O2-oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) and O2-substituted 1-[(2-carboxylato)pyrrolidin-1-y]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)öyrrolidin-1-yl]diazeniumdiolates). The O2-aryl diazeniumdiolates are stable with respect to the hydrolytic generation of nitric oxide in neutral to acidic solutions and generate nitric oxide in basic or nucleophilic environments or microenvironments. Also provided are compositions, including pharmaceutical compositions, comprising such compounds and methods of using such compounds.

  提供了 N1 位被无机或有机分子取代且 O2-氧与取代或未取代的芳香基团结合的重氮鎓二元醇盐。还提供了 O2-糖基化的 1-取代二氮-1-鎓-1,2-二元醇盐（O2-糖基化二氮二元醇盐）和 O2-取代的 1-[(2-羧基)吡咯烷-1-y]二氮-1-鎓-1,2-二元醇盐（1-[(2-羧基)öyrrolidin-1-yl]二氮二元醇盐）。在中性至酸性溶液中，O2-芳基重氮二元醇盐在水解生成一氧化氮方面是稳定的，在碱性或亲核性环境或微环境中生成一氧化氮。此外，还提供了包含此类化合物的组合物（包括药物组合物）和使用此类化合物的方法。
• Studies on Condensed Pyrimidine Systems. XIII. Some Amino-substituted Derivatives of Guanine and 6-Thioguanine
  作者：Gertrude B. Elion、William H. Lange、George H. Hitchings

  DOI：10.1021/ja01582a060

  日期：1956.1