N,5-二羟基-2-甲氧基苯甲酰胺 | 1083407-17-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: N,5-二羟基-2-甲氧基苯甲酰胺
• 英文名称: N,5-dihydroxy-2-methoxybenzamide
• CAS: 1083407-17-3
• 化学式: C₈H₉NO₄
• 分子量: 183.164
• InChiKey: VVLCYQFXGFTUDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,5-二羟基-2-甲氧基苯甲酰胺 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 以89%的产率得到2-溴-5-甲氧基苯甲酸甲酯
  参考文献：
  名称：

  Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases

  摘要：

  The dynamic methylation of histone lysyl residues plays an important role in biology by regulating transcription, maintaining genomic integrity, and by contributing to epigenetic effects. Here we describe a variety of inhibitor scaffolds that inhibit the human 2-oxoglutarate-dependent JMJD2 subfamily of histone demethylases. Combined with structural data, these chemical starting points will be useful to generate small-molecule probes to analyze the physiological roles of these enzymes in epigenetic signaling.

  DOI：

  10.1021/jm800936s
• 作为产物：
  描述：

  N-(benzyloxy)-5-hydroxy-2-methoxybenzamide 在 palladium 10% on activated carbon 氢气 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以89%的产率得到N,5-二羟基-2-甲氧基苯甲酰胺
  参考文献：
  名称：

  [EN] HISTONE LYSINE DEMETHYLASE INHIBITORS
  [FR] INHIBITEURS D'HISTONE LYSINE DÉMÉTHYLASE

  摘要：

  公开号：

  WO2010043866A3

文献信息

• METHOD OF PREVENTING OR TREATING VIRAL INFECTION
  申请人：Department of Health and Human Services The United States of America, as Represented by the Secretary,

  公开号：US20130123344A1

  公开（公告）日：2013-05-16

  Disclosed are compounds and pharmaceutical compositions containing compounds that inhibit JMJD2 proteins, including those of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein or pharmaceutically acceptable salts thereof. Also disclosed is a method of preventing or treating a viral infection of a host, comprising administering to the host an effective amount of an inhibitor of the JMJD2 family of histone demethylases, for example, a compound of the formula (I). The viral infection may be a primary infection, reactivation of a virus after latency in a host, or may be in a mammal that has undergone, is undergoing, or will undergo immunosuppressive therapy.
• US8871789B2
  申请人：——

  公开号：US8871789B2

  公开（公告）日：2014-10-28
• [EN] METHOD OF PREVENTING OR TREATING VIRAL INFECTION<br/>[FR] MÉTHODE DESTINÉE À PRÉVENIR OU À TRAITER UNE INFECTION VIRALE
  申请人：US HEALTH

  公开号：WO2012012627A1

  公开（公告）日：2012-01-26

  Disclosed are compounds and pharmaceutical compositions containing compounds that inhibit JMJD2 proteins, including those of the formula (I): wherein R1, R2, R3, R4, and R5 are as defined herein or pharmaceutically acceptable salts thereof. Also disclosed is a method of preventing or treating a viral infection of a host, comprising administering to the host an effective amount of an inhibitor of the JMJD2 family of histone demethylases, for example, a compound of the formula (I). The viral infection may be a primary infection, reactivation of a virus after latency in a host, or may be in a mammal that has undergone, is undergoing, or will undergo immunosuppressive therapy.
• [EN] HISTONE LYSINE DEMETHYLASE INHIBITORS<br/>[FR] INHIBITEURS D'HISTONE LYSINE DÉMÉTHYLASE
  申请人：ISIS INNOVATION

  公开号：WO2010043866A3

  公开（公告）日：2010-10-07
• Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases
  作者：Nathan R. Rose、Stanley S. Ng、Jasmin Mecinović、Benoît M.R. Liénard、Simon H. Bello、Zhe Sun、Michael A. McDonough、Udo Oppermann、Christopher J. Schofield

  DOI：10.1021/jm800936s

  日期：2008.11.27

  The dynamic methylation of histone lysyl residues plays an important role in biology by regulating transcription, maintaining genomic integrity, and by contributing to epigenetic effects. Here we describe a variety of inhibitor scaffolds that inhibit the human 2-oxoglutarate-dependent JMJD2 subfamily of histone demethylases. Combined with structural data, these chemical starting points will be useful to generate small-molecule probes to analyze the physiological roles of these enzymes in epigenetic signaling.