5'-O-(4-phenylbenzyl)thymidine | 167147-45-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5'-O-(4-phenylbenzyl)thymidine
• 英文别名: 1-[(2R,4S,5R)-4-hydroxy-5-[(4-phenylphenyl)methoxymethyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• CAS: 167147-45-7
• 化学式: C₂₃H₂₄N₂O₅
• 分子量: 408.454
• InChiKey: ZAHUVEOFMWQXTI-PWRODBHTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  88.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-氯甲基联苯 以47%的产率得到5'-O-(4-phenylbenzyl)thymidine
  参考文献：
  名称：

  Modified oligodeoxyribonucleoditides

  摘要：

  提供用于治疗或预防哺乳动物（可能是人类）病毒感染的化合物。这些化合物是寡脱氧核糖核酸衍生物，并提供了一种新颖的合成这些化合物的途径，以及更普遍有用的中间体。活性化合物的一般结构式为（1）：其中R.sub.1、R.sub.2和R.sub.3是氢原子、烷基、所定义的芳基和蒽醌基；Z是碳或硅；或者R.sub.2、R.sub.3和Z一起代表芴基或蒽基；R.sub.4是氢原子、所定义的烷基、所定义的芳基；Y.sub.1、Y.sub.3和Y.sub.4是氧、硫或>NH；Y.sub.2是氧、硫、>NH、烷基或苯基；X是所定义的烷基；m和n为0至10；B是链长为3至9的寡脱氧核糖核苷酸；或其盐。

  公开号：

  US05674856A1

文献信息

• Thymine derivatives and quinazoline-dione derivatives for the inhibition of HSP27
  申请人：TECHNISCHE UNIVERSITAET DRESDEN

  公开号：US10940150B2

  公开（公告）日：2021-03-09

  The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.

  本发明涉及新型HSP27抑制剂，特别是根据通式（VI）、（VII）或（VII）的胸腺嘧啶衍生物和根据式（V）的吩噻嗪衍生物，以及它们作为选择性抑制热休克蛋白HSP27（HSPB1）的药物的用途，特别是用于治疗癌症或囊性纤维化，所述抑制剂在较低的微摩尔或亚微摩尔活性成分浓度范围内对HSP27具有特别有利的活性。
• Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0611075B1

  公开（公告）日：1996-12-18
• EFFICIENT INHIBITION OF HSP27
  申请人：TECHNISCHE UNIVERSITAET DRESDEN

  公开号：US20170216297A1

  公开（公告）日：2017-08-03

  The present invention relates to novel HSP27 inhibitors, in particular purine derivatives according to general formula (I) or (II) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP2.
• THYMINE DERIVATIVES AND QUINAZOLINE-DIONE DERIVATIVES FOR THE INHIBITION OF HSP27
  申请人：TECHNISCHE UNIVERSITAET DRESDEN

  公开号：US20180207160A1

  公开（公告）日：2018-07-26

  The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.
• US5674856A
  申请人：——

  公开号：US5674856A

  公开（公告）日：1997-10-07