Diethyl-diphosphonsaeure-diisopropylester | 55421-90-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Diethyl-diphosphonsaeure-diisopropylester
• 英文别名: Diisopropyl-ethylpyrophosphonat；ethylphosphonic acid-anhydride-isopropyl ester；Bis-(aethylphosphonsaeure-isopropylester)-anhydrid；Aethylphosphosphonsaeure-anhydrid-isopropylester；2-[Ethyl-[ethyl(propan-2-yloxy)phosphoryl]oxyphosphoryl]oxypropane；2-[ethyl-[ethyl(propan-2-yloxy)phosphoryl]oxyphosphoryl]oxypropane
• CAS: 55421-90-4
• 化学式: C₁₀H₂₄O₅P₂
• 分子量: 286.245
• InChiKey: BVVLAPXFPMIUOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  Ethylphosphonsaeure-isopropylester-chlorid 在 吡啶 、 水 作用下， 生成 Diethyl-diphosphonsaeure-diisopropylester
  参考文献：
  名称：

  Coe et al., Journal of the Chemical Society, 1957, p. 3604,3606

  摘要：

  DOI：

文献信息

• Sosnovsky,S.; Konieczny,M., Phosphorus and the Related Group V Elements, 1974, vol. 4, p. 255 - 264
  作者：Sosnovsky,S.、Konieczny,M.

  DOI：——

  日期：——
• Coe et al., Journal of the Chemical Society, 1957, p. 3604,3606
  作者：Coe et al.

  DOI：——

  日期：——
• Chymase Participates in Chronic Dermatitis by Inducing Eosinophil Infiltration
  作者：Yoshiaki Tomimori、Tsuyoshi Muto、Harukazu Fukami、Kayo Saito、Chika Horikawa、Nobuo Tsuruoka、Masayuki Saito、Namino Sugiura、Kyoko Yamashiro、Motoo Sumida、Saki Kakutani、Yoshiaki Fukuda

  DOI：10.1097/01.lab.0000018827.78602.f4

  日期：2002.6

  An epicutaneous application of 2,4-dinitrofluorobenzene (DNFB) to a mouse ear caused a transient skin swelling, and the repetition of the challenge enlarged the contact dermattis. The repeated challenge with DNFB also induced eosinophil infiltration on the application site. Administration of a chymase inhibitor significantly inhibited the ear swelling as well as eosinophil accumulation. An intradermal injection of human chymase to the mouse ear also elicited transient skin swelling and eosinophil infiltration, both of which were augmented in proportion to the number of injections. Human serum albumin and heat-inactivated chymase failed to induce such skin reactions, suggesting the participation of proteolytic activity of the enzyme. In addition, chymase stimulated eosinophil migration in vitro in a concentration-dependent manner. Taken together, these observations suggest that mast cell chymase may contribute to development of the DNFB-induced dermatitis, probably by promoting eosinophil infiltration. It is therefore possible that chymase plays a role in pathogenesis of chronic dermatitis such as atopic dermatitis.