7,8-Dihydro-5a-methyl-10H-1,3-dioxolo[4,5-g]oxazolo[2,3-b][1,3]benzoxazin-10-one | 230302-93-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 7,8-Dihydro-5a-methyl-10H-1,3-dioxolo[4,5-g]oxazolo[2,3-b][1,3]benzoxazin-10-one
• 英文别名: 3-methyl-2,4,12,14-tetraoxa-7-azatetracyclo[7.7.0.03,7.011,15]hexadeca-1(16),9,11(15)-trien-8-one
• CAS: 230302-93-9
• 化学式: C₁₂H₁₁NO₅
• 分子量: 249.223
• InChiKey: PKHAPJPSNGPYIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  57.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-甲基-2-恶唑啉 、 6-hydroxybenzo[d][1,3]dioxole-5-carboxylic acid 在 氯化亚砜 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 以64%的产率得到7,8-Dihydro-5a-methyl-10H-1,3-dioxolo[4,5-g]oxazolo[2,3-b][1,3]benzoxazin-10-one
  参考文献：
  名称：

  Benzoxazine compounds for enhancing synaptic response

  摘要：

  揭示了具有特定苯并噁嗪环系统及其前体的化合物，这些化合物对通过AMPA受体介导的突触响应有益。还公开了制备此类化合物的方法，以及用于治疗因兴奋性突触数量不足或AMPA受体数量不足而导致神经或智力功能受损的受试者的方法。这些发明化合物还可用于治疗非受损受试者，以增强依赖AMPA受体的大脑网络执行感觉运动和认知任务的性能，并改善记忆编码。

  公开号：

  US05985871A1

文献信息

• Compositions for enhancing memory and methods therefor
  申请人：Baudry Michel

  公开号：US20060063707A1

  公开（公告）日：2006-03-23

  Compositions for enhancing memory of a subject comprising a combination of a positive modulator of an AMPA receptor and a positive modulator of an NMDA receptor are provided, wherein each modulator of the combination is present at a subtherapeutic dose for effecting memory enhancement. Methods for using such compositions in the treatment of cognitive impairment associated with aging, age-related diseases, and CNS disorders, for example, are provided. New fusion molecules are also provided that combine the positive modulator functionalities into one molecule.

  提供了用于增强主体记忆的组合物，包括AMPA受体的正调节剂和NMDA受体的正调节剂，其中组合物中的每种调节剂均以次治疗剂量存在，以实现记忆增强效果。提供了在治疗与衰老、与年龄相关的疾病和中枢神经系统疾病相关的认知障碍中使用这种组合物的方法。还提供了将正调节剂功能结合到一个分子中的新融合分子。
• US5985871A
  申请人：——

  公开号：US5985871A

  公开（公告）日：1999-11-16
• [EN] COMPOSITIONS FOR ENHANCING MEMORY AND METHODS THEREFOR<br/>[FR] COMPOSITIONS POUR RENFORCER LA MÉMOIRE ET PROCÉDÉS IDOINES
  申请人：LIFELIKE BIOMATIC INC

  公开号：WO2006034196A1

  公开（公告）日：2006-03-30

  Compositions for enhancing memory of a subject comprising a combination of a positive modulator of an AMPA receptor and a positive modulator of an NMDA receptor are provided, wherein each modulator of the combination is present at a subtherapeutic dose for effecting memory enhancement. Methods for using such compositions in the treatment of cognitive impairment associated with aging, age-related diseases, and CNS disorders, for example, are provided. New fusion molecules are also provided that combine the positive modulator functionalities into one molecule.
• Benzoxazine compounds for enhancing synaptic response
  申请人：Cortex Pharmaceuticals, Inc.

  公开号：US05985871A1

  公开（公告）日：1999-11-16

  Compounds having a certain benzoxazine ring system and their precursors are disclosed which are useful for enhancing synaptic responses mediated by AMPA receptors. Also disclosed are methods for preparing such compounds, and methods for their use in treating subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number of excitatory synapses or in the number of AMPA receptors. The invention compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors and for improving memory encoding.

  揭示了具有特定苯并噁嗪环系统及其前体的化合物，这些化合物对通过AMPA受体介导的突触响应有益。还公开了制备此类化合物的方法，以及用于治疗因兴奋性突触数量不足或AMPA受体数量不足而导致神经或智力功能受损的受试者的方法。这些发明化合物还可用于治疗非受损受试者，以增强依赖AMPA受体的大脑网络执行感觉运动和认知任务的性能，并改善记忆编码。