5-fluoro-N,N-dimethyl-2-(3-(trimethylsilyl)propoxy)pyrimidin-4-amine | 1435520-82-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-fluoro-N,N-dimethyl-2-(3-(trimethylsilyl)propoxy)pyrimidin-4-amine
• 英文别名: 5-fluoro-N,N-dimethyl-2-(3-trimethylsilylpropoxy)pyrimidin-4-amine
• CAS: 1435520-82-3
• 化学式: C₁₂H₂₂FN₃OSi
• 分子量: 271.41
• InChiKey: WETCWGBMKIQFHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.79
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-(三甲硅基)-1-丙醇 、 2-氯-4-(二甲基氨基)-5-氟嘧啶 在 CH₃O₃S^(1-)*C₃₁H₄₉OP*C₁₂H₉NPd⁽¹⁺⁾ 、 caesium carbonate 作用下， 以 甲苯 为溶剂， 反应 16.0h， 以77%的产率得到5-fluoro-N,N-dimethyl-2-(3-(trimethylsilyl)propoxy)pyrimidin-4-amine
  参考文献：
  名称：

  Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands

  摘要：

  A series of palladacyclic precatalysts that incorporate electron-rich di-fert-butylphosphino biaryl ligands is reported. These precatalysts are easily prepared, and their use provides a general means of employing bulky ligands in palladium-catalyzed cross-coupling reactions. The application of these palladium sources to various C-N and C-O bond-forming processes is also described.

  DOI：

  10.1021/ol401208t

文献信息

• Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-<i>tert</i>-butylphosphino Biaryl Ligands
  作者：Nicholas C. Bruno、Stephen L. Buchwald

  DOI：10.1021/ol401208t

  日期：2013.6.7

  A series of palladacyclic precatalysts that incorporate electron-rich di-fert-butylphosphino biaryl ligands is reported. These precatalysts are easily prepared, and their use provides a general means of employing bulky ligands in palladium-catalyzed cross-coupling reactions. The application of these palladium sources to various C-N and C-O bond-forming processes is also described.