N,N'-二乙基-6-哌啶-1,3,5-三嗪-2,4-二胺 | 16268-60-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N,N'-二乙基-6-哌啶-1,3,5-三嗪-2,4-二胺
• 英文名称: N2,N4-diethyl-6-(piperidin-1-yl)-1,3,5-triazine-2,4-diamine
• 英文别名: N,N'-diethyl-6-piperidin-1-yl-[1,3,5]triazine-2,4-diamine；2-Piperidino-4.6-bis-ethylamino-s-triazin；s-Triazine, 2,4-bis(ethylamino)-6-piperidino-；2-N,4-N-diethyl-6-piperidin-1-yl-1,3,5-triazine-2,4-diamine
• CAS: 16268-60-3
• 化学式: C₁₂H₂₂N₆
• mdl: MFCD01679099
• 分子量: 250.347
• InChiKey: BAMOQYHMXONIIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  66
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  2,4-dichloro-6-piperidin-1-yl-[1,3,5]triazine 、 乙胺 以 水 、 丙酮 为溶剂， 反应 8.0h， 以64%的产率得到N,N'-二乙基-6-哌啶-1,3,5-三嗪-2,4-二胺
  参考文献：
  名称：

  Discovery of new 1,3,5-triazine scaffolds with potent activity against Mycobacterium tuberculosis H37Rv

  摘要：

  A series of eighty one 2,4,6-trisubstituted-1,3,5-triazines were synthesized and evaluated in vitro for the growth inhibition of Mycobacterium tuberculosis H37Rv. Fifteen compounds from this series exhibited good to moderate activity with an MIC in the range 1.56-3.12 mu g/mL and most of them were found to be nontoxic against VERO cells and MBMDMQs (mouse bone marrow derived macrophages). This is for the first time that 2,4,6-trisubstituted-1,3,5-triazines were identified as a potent inhibitors of M. tuberculosis H37Rv. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.04.017

文献信息

• EPOXY/ACID ANHYDRIDE COMPOSITION
  申请人：NISSAN CHEMICAL INDUSTRIES, LIMITED

  公开号：EP0834523A1

  公开（公告）日：1998-04-08

  (Object) It is to provide an epoxy/acid anhydride composition comprising an epoxy compound and an acid anhydride serving as a curing agent wherein a substituted triazine of a specific structure is employed as a curing accelerator to thereby impart a long pot life, a high storage stability and good working characteristics to the composition and cause no defect such as bubbling or cracking in the cured resin. (Constitution of the invention) An epoxy/acid anhydride composition characterized by containing, as a curing accelerator, a substituted triazine of the formula [] (wherein X is an amino group, C1-18 monoalkylamino group, di C1-18 alkylamino group, morpholino group, piperidino group, methyl group or phenyl group; R1 and R2 independently each represent C1-12 alkyl group, C1-12 hydroxyalkyl group, C4-8 cycloalkyl group, C5-9 cycloalkylmethyl group or C5-9 methylcycloalkyl group) in an epoxy/acid anhydride composition in which an epoxy compound and an acid anhydride-curing agent are contained, and an epoxy/acid anhydride resin composition prepared by thermosetting the epoxy/acid anhydride composition.

  目的 提供一种环氧/酸酐组合物，该组合物由环氧化合物和用作固化剂的酸酐组成，其中使用了特定结构的取代三嗪作为固化促进剂，从而使该组合物具有较长的固化寿命、较高的储存稳定性和良好的工作特性，并且不会导致固化树脂出现气泡或开裂等缺陷。 (本发明的结构） 一种环氧树脂/酸酐组合物，其特征在于含有式[]的取代三嗪作为固化促进剂。 (其中 X 是氨基、C1-18 单烷基氨基、二 C1-18 烷基氨基、吗啉基、哌啶基、甲基或苯基；R1 和 R2 各自独立地代表环氧化合物和酸酐固化剂的环氧/酸酐组合物中的 C1-12 烷基、C1-12 羟基烷基、C4-8 环烷基、C5-9 环烷基甲基或 C5-9 甲基环烷基），以及通过热固化该环氧/酸酐组合物制备的环氧/酸酐树脂组合物。
• Discovery of new 1,3,5-triazine scaffolds with potent activity against Mycobacterium tuberculosis H37Rv
  作者：Naresh Sunduru、Leena Gupta、Vinita Chaturvedi、Richa Dwivedi、Sudhir Sinha、Prem M.S. Chauhan

  DOI：10.1016/j.ejmech.2010.04.017

  日期：2010.8

  A series of eighty one 2,4,6-trisubstituted-1,3,5-triazines were synthesized and evaluated in vitro for the growth inhibition of Mycobacterium tuberculosis H37Rv. Fifteen compounds from this series exhibited good to moderate activity with an MIC in the range 1.56-3.12 mu g/mL and most of them were found to be nontoxic against VERO cells and MBMDMQs (mouse bone marrow derived macrophages). This is for the first time that 2,4,6-trisubstituted-1,3,5-triazines were identified as a potent inhibitors of M. tuberculosis H37Rv. (C) 2010 Elsevier Masson SAS. All rights reserved.