3-hydroxypyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione | 40338-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 3-hydroxypyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
• 英文别名: 3-Hydroxypyrido<4,3-d>pyrimidin-2,4(1H,3H)dion；3-hydroxy-1H-pyrido[4,3-d]pyrimidine-2,4-dione；3-hydroxy-1H-pyrido[4,3-d]pyrimidine-2,4-dione
• CAS: 40338-58-7
• 化学式: C₇H₅N₃O₃
• 分子量: 179.135
• InChiKey: GONFEQTYWALNBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] 3-HYDROXY-QUINAZOLINE-2,4-DIONE DERIVATIVES AND THEIR USE AS NUCLEASE MODULATORS<br/>[FR] DÉRIVÉS DE 3-HYDROXY-QUINAZOLINE-2,4-DIONE ET LEUR UTILISATION COMME MODULATEURS DE NUCLÉASE
  申请人：LUDWIG INST FOR CANCER RES LTD

  公开号：WO2017051251A1

  公开（公告）日：2017-03-30

  Described inter alia are compounds according to formula (I): or a pharmaceutically acceptable salt thereof, and uses in methods for the modulation of flap endonuclease 1 (FENl), Xeroderma Pigmentosum Complementation Group G protein (XPG), Exonuclease 1 (EXOl) and/or GEN1.

  描述的化合物如下所示：或其药用盐，并用于调节翻翼核酸酶1（FEN1）、色素沉着性皮肤干裂症补体G蛋白（XPG）、外切核酸酶1（EXO1）和/或GEN1的方法中。
• 3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators
  申请人：Ludwig Institute for Cancer Research Ltd

  公开号：US11253521B2

  公开（公告）日：2022-02-22

  Described inter alia are compounds according to formula (I): or a pharmaceutically acceptable salt thereof, and uses in methods for the modulation of flap endonuclease 1 (FEN1), Xeroderma Pigmentosum Complementation Group G protein (XPG), Exonuclease 1 (EXO1) and/or GEN1.

  除其他外，描述了根据式 (I) 的化合物：或其药学上可接受的盐，以及在调节瓣膜内切酶 1 (FEN1)、色素沉着病补体 G 组蛋白 (XPG)、外切酶 1 (EXO1) 和/或 GEN1 的方法中的用途。
• 3-HYDROXY-QUINAZOLINE-2,4-DIONE DERIVATIVES AND THEIR USE AS NUCLEASE MODULATORS
  申请人：Ludwig Institute for Cancer Research Ltd

  公开号：US20200237763A1

  公开（公告）日：2020-07-30

  Described inter alia are compounds according to formula (I): or a pharmaceutically acceptable salt thereof, and uses in methods for the modulation of flap endonuclease 1 (FEN1), Xeroderma Pigmentosum Complementation Group G protein (XPG), Exonuclease 1 (EXO1) and/or GEN1.