tert-butyl 4-(isoquinolin-1-yloxy)piperidine-1-carboxylate | 817187-34-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: tert-butyl 4-(isoquinolin-1-yloxy)piperidine-1-carboxylate
• 英文别名: 1-tert-butoxycarbonyl-4-(1-isoquinolinyloxy)-piperidine；tert-butyl 4-isoquinolin-1-yloxypiperidine-1-carboxylate
• CAS: 817187-34-1
• 化学式: C₁₉H₂₄N₂O₃
• 分子量: 328.411
• InChiKey: RAQXGVHGOSLHBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  51.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-氯异喹啉 、 N-Boc-4-羟基哌啶 在 crown ether 、 potassium tert-butylate 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 以100%的产率得到tert-butyl 4-(isoquinolin-1-yloxy)piperidine-1-carboxylate
  参考文献：
  名称：

  [EN] AZA-RING DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
  [FR] DERIVES DE NOYAUX AZA ET UTILISATION DE CEUX-CI COMME INHIBITEURS DE LA RECAPTURE DES NEUROTRANSMETTEURS MONOAMINERGIQUES

  摘要：

  公开号：

  WO2004113297A3

文献信息

• Novel aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
  申请人：Peters Dan

  公开号：US20070021404A1

  公开（公告）日：2007-01-25

  This invention relates to novel aza-ring derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

  本发明涉及新型的氮杂环衍生物，可作为单胺神经递质再摄取抑制剂。在其他方面，本发明涉及使用这些化合物的治疗方法，以及包含本发明化合物的药物组合物。
• QUINOLONE DERIVATIVE HAVING INDOLEAMINE-2,3-DIOXYGENASE INHIBITED ACTIVITY
  申请人：Shenzhen Chipscreen Biosciences Co., Ltd.

  公开号：EP3858813A1

  公开（公告）日：2021-08-04

  Provided is a quinoline derivative having indoleamine-2,3-dioxygenase inhibitory activity, specifically, provided is a compound of general Formula (I) or pharmaceutically acceptable salt thereof, its pharmaceutical composition, preparation method and use in the manufacture of a medicament for immunomodulating and preventing and/or treating of a disease associated with IDO expression abnormality and/or tryptophan metabolism abnormality. Also provided is use of a combination medication of the quinoline derivative and HDAC inhibitor and its use in the manufacture of an anti-tumor drug.         A-X-B-Y-M     Formula (I)

  本发明提供了一种具有吲哚胺-2,3-二氧化酶抑制活性的喹啉衍生物，具体地说，提供了通式（I）的化合物或其药学上可接受的盐、其药物组合物、制备方法以及在制造用于免疫调节和预防和/或治疗与IDO表达异常和/或色氨酸代谢异常相关的疾病的药物中的用途。此外，还提供了喹啉衍生物和 HDAC 抑制剂的联合用药及其在制造抗肿瘤药物中的用途。 A-X-B-Y-M 分子式 (I)
• PYRROLIDINE AND PIPERIDINE COMPOUNDS
  申请人：Yuhan Corporation

  公开号：EP4055014A1

  公开（公告）日：2022-09-14
• QUINOLINE DERIVATIVE HAVING INDOLEAMINE-2,3-DIOXYGENASE INHIBITORY ACTIVITY
  申请人：SHENZHEN CHIPSCREEN BIOSCIENCES CO., LTD.

  公开号：US20210379052A1

  公开（公告）日：2021-12-09

  Provided is a quinoline derivative having indoleamine-2,3-dioxygenase inhibitory activity, specifically, provided is a compound of general Formula (I) or pharmaceutically acceptable salt thereof, its pharmaceutical composition, preparation method and use in the manufacture of a medicament for immunomodulating and preventing and/or treating of a disease associated with IDO expression abnormality and/or tryptophan metabolism abnormality. Also provided is use of a combination medication of the quinoline derivative and HDAC inhibitor and its use in the manufacture of an anti-tumor drug. A-X—B—Y-M   Formula (I)
• [EN] AZA-RING DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS<br/>[FR] DERIVES DE NOYAUX AZA ET UTILISATION DE CEUX-CI COMME INHIBITEURS DE LA RECAPTURE DES NEUROTRANSMETTEURS MONOAMINERGIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2004113297A3

  公开（公告）日：2006-01-19