4,6-Dideoxyhexopyranose | 29325-32-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 4,6-Dideoxyhexopyranose
• 英文别名: 6-methyloxane-2,3,4-triol
• CAS: 29325-32-4
• 化学式: C₆H₁₂O₄
• 分子量: 148.16
• InChiKey: BJBURJZEESAQPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] PROCESS FOR PRODUCTION OF ASCARYLOSE AND RELATED COMPOUNDS<br/>[FR] PROCÉDÉ DE PRODUCTION D'ASCARYLOSE ET DE COMPOSÉS APPARENTÉS
  申请人：ASCRIBE BIOSCIENCE

  公开号：WO2022024067A1

  公开（公告）日：2022-02-03

  This application relates to efficient methods for the synthesis of ascarylose and its derivatives. A method for the production of ascarylose includes: providing, as a feedstock, a 1-O-substituted rhamnose; forming a mono-sulfonate ester at the 3-OH group of the 1-O-substituted rhamnose; and treating the mono-sulfonate ester with a hydride source to form a 1-O-substituted ascarylose. Forming the mono-sulfonate ester can advantageously be conducted on a 1-O-substituted rhamnose without hydroxyl protecting groups at either the 2-OH or 4-OH-positions.

  本申请涉及制备ascarylose及其衍生物的高效方法。一种制备ascarylose的方法包括：提供1-O-取代的鼠李糖作为原料；在1-O-取代的鼠李糖的3-OH基团上形成单磺酸酯；并使用氢化物来源处理单磺酸酯以形成1-O-取代的ascarylose。优选地，在2-OH或4-OH位置均不具有羟基保护基团的1-O-取代鼠李糖上可以有利地形成单磺酸酯。
• MATERIALS AND METHODS FOR IMPROVED IMMUNOGLYCOPROTEINS
  申请人：Trubion Pharmaceuticals, Inc.

  公开号：EP2076538A2

  公开（公告）日：2009-07-08
• Materials and methods for improved immunoglycoproteins
  申请人：Espling Erik S.

  公开号：US20090041765A1

  公开（公告）日：2009-02-12

  Immunoglycoproteins, including antibodies, with improved ADCC and altered glycosylation patterns are provided. Also provided are cell culturing methods and media for producing such immunoglycoproteins, and therapeutic uses of such immunoglycoproteins.
• Materials and Methods for Improved Immunoglycoproteins
  申请人：EMERGENT PRODUCT DEVELOPMENT SEATTLE, LLC

  公开号：US20130280240A1

  公开（公告）日：2013-10-24

  Immunoglycoproteins, including antibodies, with improved ADCC and altered glycosylation patterns arc provided. Also provided are cell culturing methods and media for producing such immunoglycoproteins, and therapeutic uses of such immunoglycoproteins.
• US7846434B2
  申请人：——

  公开号：US7846434B2

  公开（公告）日：2010-12-07