9H-fluoren-9-ylmethyl 2-aminopropanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9H-fluoren-9-ylmethyl 2-aminopropanoate
• 化学式: C₁₇H₁₇NO₂
• 分子量: 267.32
• InChiKey: DJSMSZQXYHEVMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PEPTIDE-RESIN CONJUGATE AND USE THEREOF
  申请人：CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A.

  公开号：US20160137689A1

  公开（公告）日：2016-05-19

  The present invention relates to a peptide-resin conjugate of Formula (2), wherein: Pr 1 is selected from H, alkyl, aryl, aralkyl, acyl, aroyl and a protecting group; Y is a direct bond; or an optionally protected natural or unnatural amino acid residue; or a peptide comprising 2 to 200 natural or unnatural amino acid residues, each of which is optionally protected; Dia is a natural or unnatural diamino acid; A is a polymer resin conjugated to the side chain amino function of the diamino acid; X is an optionally protected natural or unnatural amino acid residue; or a peptide comprising 2 to 15 natural or unnatural amino acid residues, each of which is optionally protected; R 1 , and R 2 are each independently selected from H, alkyl, aryl, aralkyl, NH 2 , NH—CO—NH 2 . Further aspects of the invention relate to a process of preparing peptide-resin conjugates of Formula (2), and their use in the preparation of peptides.