tert-butyl 4-{[(4-oxo-1,2,3-benzotriazin-3(4H)-yl)oxy]carbonyl}benzylcarbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并-1,2,3-三嗪类化合物
• 英文名称: tert-butyl 4-{[(4-oxo-1,2,3-benzotriazin-3(4H)-yl)oxy]carbonyl}benzylcarbamate
• 英文别名: (4-oxo-1,2,3-benzotriazin-3-yl) 4-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]benzoate
• 化学式: C₂₀H₂₀N₄O₅
• 分子量: 396.4
• InChiKey: DVUVLCZMSGSJHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• TARGETING STAT SUMOYLATION TO ENHANCE IMMUNE RESPONSES
  申请人：THE GEORGE WASHINGTON UNIVERSITY

  公开号：US20210114999A1

  公开（公告）日：2021-04-22

  The present disclosure generally relates to compositions and methods for ex vivo expansion of immune cells isolated from a subject, wherein gene expression can be modulated to enhance immune cell activity in the resulting expanded immune cell culture. Modulation of gene expression in an expanded immune cell culture allows for an immune cell therapy contains genetically chemically modified immune cells suitable for the adoptive cell transfer into a subject in need thereof.