N-(1,2,2,2-四氯乙基)二氯乙酰胺 | 35530-52-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(1,2,2,2-四氯乙基)二氯乙酰胺
• 英文名称: N-(1,2,2,2-tetrachloroethyl)dichloroacetamide
• 英文别名: 2,2-dichloro-N-(1,2,2,2-tetrachloroethyl)acetamide
• CAS: 35530-52-0
• 化学式: C₄H₃Cl₆NO
• 分子量: 293.792
• InChiKey: DWAQIPQGDBKYDQ-UHFFFAOYSA-N

物化性质

• 沸点：
  330.3±42.0 °C(Predicted)
• 密度：
  1.732±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(1,2,2,2-四氯乙基)二氯乙酰胺 在 五氯化磷 、 三氯氧磷 作用下， 生成
  参考文献：
  名称：

  Drach,B.S. et al., Journal of Organic Chemistry USSR (English Translation), 1979, vol. 15, p. 32 - 36

  摘要：

  DOI：
• 作为产物：
  描述：

  二氯-乙酸-(2,2,2-三氯-1-羟基-乙基酰胺) 在 五氯化磷 作用下， 以 苯 为溶剂， 生成 N-(1,2,2,2-四氯乙基)二氯乙酰胺
  参考文献：
  名称：

  Drach,B.S. et al., Journal of Organic Chemistry USSR (English Translation), 1979, vol. 15, p. 32 - 36

  摘要：

  DOI：

文献信息

• Dichloroacetamide and trichloroacetamide derivatives which are antidotes
  申请人：PCUK Produits Chimiques Ugine Kuhlmann

  公开号：US04330323A1

  公开（公告）日：1982-05-18

  The compounds of the formula: ##STR1## in which R.sub.1 represents a dichloromethyl or trichloromethyl group, X.sub.1 represents a chlorine or fluorine atom, X.sub.2 represents a chlorine or fluorine atom, X.sub.3 represents a hydrogen, chlorine or fluorine atom, R.sub.2 represents an amino group NH.sub.2 or a ##STR2## group, in which R.sub.3 represents a hydrogen atom or an alkyl, haloalkyl, alkenyl, haloalkenyl, arylalkyl, arylhaloalkyl, cycloalkyl, halocycloalkyl, alkoxyalkyl, haloalkoxyalkyl or aryl group, this latter being unsubstituted or substituted by one or two halogen atoms or by an alkyl, alkoxy, nitro or haloalkyl group are antidotes against herbicides.

  式为：##STR1##的化合物，其中R.sub.1代表二氯甲基或三氯甲基基团，X.sub.1代表氯或氟原子，X.sub.2代表氯或氟原子，X.sub.3代表氢、氯或氟原子，R.sub.2代表氨基NH.sub.2或##STR2##基团，其中R.sub.3代表氢原子或烷基、卤代烷基、烯基、卤代烯基、芳基烷基、芳基卤代烷基、环烷基、卤代环烷基、烷氧基烷基、卤代烷氧基烷基或芳基基团，后者未取代或被一个或两个卤素原子或烷基、烷氧、硝基或卤代烷基基团取代，是除草剂的解毒剂。
• Derivatives of 5-(Dimethylamino)-4-tosyl-1,3-oxazole-2-carbaldehyde and Its Analogs
  作者：R. N. Vyzhdak、A. A. Danielova、V. V. Kiselev、B. S. Drach

  DOI：10.1007/s11176-005-0350-7

  日期：2005.6

  oxazole series, whose facile acid hydrolysis provided 5-(dimethylamino)-4-tosyl-1,3-oxazol-2-carbaldehyde and its analogs having the piperidino and morpholino group in the 5 position of the oxazole ring. The resulting aldehydes and their aminals were condensed with phenylhydrazine, thiosemicarbazide, N -alkylrhodanines, and 1,3-dimethylbarbituric acid to obtain 2,5-disubstituted derivatives of 4-tosyl-1

  用过量的二甲胺，哌啶或吗啉处理 N- （2,2,2-三氯-1-甲苯磺酰基乙基）二氯乙酰胺，得到恶唑系列的取代缩醛，其容易的酸水解提供了5-（二甲氨基）-4-甲苯磺酰基-1在恶唑环的5位具有哌啶子基和吗啉代基团的1，3-恶唑-2-甲醛及其类似物。将得到的醛及其缩醛与苯肼，硫代氨基脲， N- 烷基罗丹宁和1，3-二甲基巴比妥酸缩合，得到4-甲苯基-1，3-恶唑的2，5-二取代衍生物。
• DE1946112
  申请人：——

  公开号：——

  公开（公告）日：——
• ——
  作者：S. G. Pil'o

  DOI：10.1023/a:1023385028068

  日期：——

  Polychlorinated enamidonitrile Cl2C=C(CN)NHCOCHCl2, readily reacts with primary aromatic amines, dialkylamines, piperidine, and morpholine. The reaction is accompanied by complete elimination of chlorine atoms as chloride ions with formation of 4-cyanooxazoles having the corresponding amine residue in position 5 of the ring and a CH=N or diaminomethyl moiety in position 2. The structure of 5-arylamino(dialkylamino)-4-cyano-2-formyloxazoles was confirmed by their acid hydrolysis, as well as by the condensation with phenylhydrazine, N-alkylrhodanines, and ethyl acetoacetate in the presence of urea.
• ——
  作者：R. N. Vydzhak、V. S. Brovarets、S. G. Pil'o、B. S. Drach

  DOI：10.1023/a:1015461315727

  日期：——

  Available N-(1,2,2,2-tetrachloroethyl)dichloroacetamide selectively reacts with trialkyl phosphites and triphenylphosphine, which was used for preparing polycentered electrophilic agents unusually reacting with piperidine and morpholine in the presence of water to give in high yields 4-dialkoxyphosphoryl- or 4-triphenylphosphonio-substituted oxazole-2-carbaldehydes containing piperidine or morpholine moiety in the 5-position. Their structure was determined by spectroscopy and also by chemical transformations into phenylhydrazones, thiosemicarbazones, aminals, and other functional derivatives of these two types of phosphorus-containing aldehydes of the oxazole series.