N-(1,2,3,4-四氢-4-氧代-1-萘)-乙酰胺 | 67614-68-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: N-(1,2,3,4-四氢-4-氧代-1-萘)-乙酰胺
• 英文名称: N-(4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)acetamide
• 英文别名: N-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)acetamide；N-(1,2,3,4-tetrahydro-4-oxo-1-naphtyl)acetamide；N-(4-Oxo-1,2,3,4-tetrahydronaphthalen-1-YL)acetamide；N-(4-oxo-2,3-dihydro-1H-naphthalen-1-yl)acetamide
• CAS: 67614-68-0
• 化学式: C₁₂H₁₃NO₂
• 分子量: 203.241
• InChiKey: YULURBVSUMMOKE-UHFFFAOYSA-N

物化性质

• 熔点：
  138-139 °C
• 沸点：
  423.8±35.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1,2,3,4-四氢-4-氧代-1-萘)-乙酰胺 在 盐酸 作用下， 以 水 为溶剂， 生成 4-氨基-3,4-二氢-2H-萘-1-酮
  参考文献：
  名称：

  Novel 1,2,3,4-tetrahydro-4-oxo-(oxy)-1-naphthylamines and method of

  摘要：

  本公开说明了1,2,3,4-四氢-4-氧代-（氧基）-1-萘胺及其新型衍生物的方法，以及制备这些化合物的方法。这些新型化合物是制备1,2,3,4-四氢-4-氧代（氧基）-1-萘基脲和硫脲化合物及其某些衍生物的有用和宝贵的中间体，这些化合物是动物生长促进剂。

  公开号：

  US04049717A1
• 作为产物：
  描述：

  (R)-(+)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)acetamide 以77的产率得到N-(1,2,3,4-四氢-4-氧代-1-萘)-乙酰胺
  参考文献：
  名称：

  Chem. Eur. J. 2009, 15, 3403-3410

  摘要：

  DOI：

文献信息

• Toward a Greener Barluenga–Valdés Cross-Coupling: Microwave-Promoted C–C Bond Formation with a Pd/PEG/H₂O Recyclable Catalytic System
  作者：Diana Lamaa、Estelle Messe、Vincent Gandon、Mouad Alami、Abdallah Hamze

  DOI：10.1021/acs.orglett.9b03310

  日期：2019.11.1

  for the synthesis of 1,1-diarylethylenes using palladium catalysis has been developed. The new catalytic system based on Pd/Xphos–SO3Na or Pd/MeDavephos–CF3SO3 in PEG/H2O under microwave irradiation was found to be the best conditions for this transformation. The recyclability of the palladium catalyst system was also studied, and it was found to be active over nine runs without significant loss in its

  已开发出一种绿色的Barluenga-Valdés交叉偶联反应，利用钯催化合成1,1-二芳基乙烯。发现在微波辐射下，基于PEG / H 2 O中Pd / Xphos-SO 3 Na或Pd / MeDavephos-CF 3 SO 3的新催化体系是该转化的最佳条件。还对钯催化剂体系的可回收性进行了研究，发现钯催化剂体系在九次运行中均具有活性，而活性没有明显损失。
• Novel 1,2,3,4-tetrahydro-4-oxo-(-oxy-)-1-naphthylamines and method of
  申请人：American Cyanamid Company

  公开号：US04091018A1

  公开（公告）日：1978-05-23

  This disclosure describes 1,2,3,4-tetrahydro-4-oxo-(oxy)-1-naphthylamine and novel derivatives thereof and methods of preparation of said compounds. These novel compounds are useful and valuable intermediates for the preparation of 1,2,3,4-tetrahydro-4-oxo(oxy)-1-naphthylurea and thiourea compounds and certain derivatives thereof which are animal growth promoters.

  这份披露描述了1,2,3,4-四氢-4-氧代-1-萘胺及其新的衍生物，以及制备这些化合物的方法。这些新的化合物是有用和有价值的中间体，用于制备1,2,3,4-四氢-4-氧代-1-萘基脲和硫脲化合物以及某些衍生物，这些化合物是动物生长促进剂。
• Synthesis of 1,2,3,4-tetrahydro-4-oxo-[or oxy-]-1-naphthylureas as novel
  申请人：American Cyanamid Company

  公开号：US04089976A1

  公开（公告）日：1978-05-16

  This invention relates to novel 1,2,3,4-tetrahydro-4-oxo-[-oxy-]-1-naphthylurea compounds and their derivatives. This invention also relates to method for the preparation of said compounds. This invention further relates to methods for the use of said tetrahydro-4-oxo-[oxy-]-1-naphthylurea compounds as animal growth regulators.

  这项发明涉及新型1,2,3,4-四氢-4-氧基-[-氧基-]-1-萘酰脲化合物及其衍生物。此发明还涉及制备上述化合物的方法。此发明进一步涉及使用四氢-4-氧基-[氧基-]-1-萘酰脲化合物作为动物生长调节剂的方法。
• Process for preparing 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophenes and
  申请人：American Cyanamid Co.

  公开号：US04332724A1

  公开（公告）日：1982-06-01

  There is provided a process for the preparation of an amido or an ureido derivative of certain 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophenes or certain 1,2,3,4-tetrahydro-4-oxonaphthalenes which can be employed as an animal growth regulant. The process comprises: oxidizing in the presence of a cobalt catalyst a compound having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each a substituent selected from the group consisting of alkanoyl C.sub.1 -C.sub.7, halogen-substituted alkanoyl C.sub.1 -C.sub.7, carboalkoxy C.sub.1 -C.sub.4, ##STR2## and ##STR3## R.sub.3 is selected from the group consisting of hydrogen and alkyl C.sub.1 -C.sub.4 ; R.sub.4 is selected from the group consisting of hydr ogen, alkyl C.sub.1 -C.sub.8, alkanoyl C.sub.2 -C.sub.4, halogen-substituted alkanoyl (C.sub.2 -C.sub.4), and ##STR4## and when the ##STR5## moiety is cyclized each represents a moiety selected from the group consisting of succinimido, maleimido and phthalimido; X and Y are each a radical selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, nitro, alkyl C.sub.1 -C.sub.4 ; the racemic mixtures and the optical isomers thereof.

  提供了一种制备某些4,5,6,7-四氢-7-氧代苯并[b]噻吩或某些1,2,3,4-四氢-4-氧代萘的酰胺或脲衍生物的方法，该方法可用作动物生长调节剂。该方法包括：在钴催化剂存在下氧化具有以下式子的化合物：##STR1##其中R.sub.1和R.sub.2分别是从羧酸C.sub.1-C.sub.7，卤代烷基C.sub.1-C.sub.7，羧甲氧基C.sub.1-C.sub.4，##STR2##和##STR3##组成的取代基；R.sub.3选自氢和烷基C.sub.1-C.sub.4；R.sub.4选自氢，烷基C.sub.1-C.sub.8，酰基C.sub.2-C.sub.4，卤代酰基（C.sub.2-C.sub.4）和##STR4##当##STR5##基团环化时，每个基团代表从琥珀酰亚胺基，马来酰亚胺基和邻苯二甲酰亚胺基组成的基团；X和Y分别是从氢，氟，氯，溴，碘，硝基，烷基C.sub.1-C.sub.4组成的基团，其为外消旋混合物和其光学异构体。
• Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds
  作者：James W. Barlow、John J. Walsh

  DOI：10.1016/j.ejmech.2008.02.009

  日期：2008.12

  A novel series of amine and amide derivatives of 4-amino-3,4-dihydro-2H-naphthalen-1-one were synthesised. The amine derivatives were evaluated for mast cell stabilising activity in rodent mast cell preparations against the reference compound disodium cromoglycate and found to possess significant activity in vitro. The amide compounds were evaluated in an in vivo murine model for anti-inflammatory activity. (C) 2008 Elsevier Masson SAS. All rights reserved.