4-amino-6-(pyridin-2-yl)-1,3,5-triazin-2-ol | 130747-39-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 4-amino-6-(pyridin-2-yl)-1,3,5-triazin-2-ol
• 英文别名: 4-amino-6-pyridin-2-yl-1H-1,3,5-triazin-2-one
• CAS: 130747-39-6
• 化学式: C₈H₇N₅O
• 分子量: 189.176
• InChiKey: QXOSMNIZBOJBFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-amino-6-(pyridin-2-yl)-1,3,5-triazin-2-ol 在 三甲基溴硅烷 、 caesium carbonate 作用下， 以 二甲基亚砜 、 乙腈 为溶剂， 反应 4.0h， 生成 (2-(4-amino-6-(pyridin-2-yl)-1,3,5-triazin-2-yloxy)ethoxy)methylphosphonic acid ammonium salt
  参考文献：
  名称：

  Synthesis of O2- and N3-(2-Phosphonomethoxy)ethyl Derivatives of 6-Phenyl- and 6-Pyridinyl-5-azacytosine

  摘要：

  A series of hydrolytically stable O-2- and N-3-(2-phosphonomethoxy)ethyl (PME) derivatives of 6-phenyl, pyridin-2, -3 and -4-yl-5-azacytosines was prepared by their alkylation with diisopropyl (2-chloroethoxy)methylphosphonate followed by the deprotection. No antitumor or antiviral activity was found except for 6-(pyridin-4-yl)-1,3,5-triazine-2,4-diamine (13d) which exhibited slight activity against feline herpesvirus in CrFK cell cultures with IC50 = 6.7 mu g/mL.

  DOI：

  10.3987/com-11-12137
• 作为产物：
  描述：

  6-(2-吡啶基)-1,3,5-三嗪-2,4-二胺 在 溶剂黄146 、 亚硝酸异戊酯 作用下， 以 水 为溶剂， 以55%的产率得到4-amino-6-(pyridin-2-yl)-1,3,5-triazin-2-ol
  参考文献：
  名称：

  Synthesis of O2- and N3-(2-Phosphonomethoxy)ethyl Derivatives of 6-Phenyl- and 6-Pyridinyl-5-azacytosine

  摘要：

  A series of hydrolytically stable O-2- and N-3-(2-phosphonomethoxy)ethyl (PME) derivatives of 6-phenyl, pyridin-2, -3 and -4-yl-5-azacytosines was prepared by their alkylation with diisopropyl (2-chloroethoxy)methylphosphonate followed by the deprotection. No antitumor or antiviral activity was found except for 6-(pyridin-4-yl)-1,3,5-triazine-2,4-diamine (13d) which exhibited slight activity against feline herpesvirus in CrFK cell cultures with IC50 = 6.7 mu g/mL.

  DOI：

  10.3987/com-11-12137

文献信息

• RIBOSWITCHES
  申请人：The University Of Manchester

  公开号：EP2707487B1

  公开（公告）日：2017-10-04
• [EN] RIBOSWITCHES<br/>[FR] RIBORÉGULATEURS
  申请人：UNIV MANCHESTER

  公开号：WO2012153142A2

  公开（公告）日：2012-11-15

  The present invention relates to a system comprising a genetic construct a riboswitch operably linked to a regulatory sequence, and a second genetic construct a coding sequence whose expression is capable of being regulated by a gene product of the first construct. Also provided is a genetic construct comprising one or more riboswitches for regulation of gene expression, wherein preferably a spacer sequence is provided downstream of the riboswitch to enhance expression of a coding sequence which is operably linked to a riboswitch. Ligands, kits, methods, host cells and expression systems are also provided.
• Synthesis of O2- and N3-(2-Phosphonomethoxy)ethyl Derivatives of 6-Phenyl- and 6-Pyridinyl-5-azacytosine
  作者：Miroslav Otmar、Martin Dracinsky、Marcela Krecmerova、Jan Balzarini、Graciela Andrei、Robert Snoeck

  DOI：10.3987/com-11-12137

  日期：——

  A series of hydrolytically stable O-2- and N-3-(2-phosphonomethoxy)ethyl (PME) derivatives of 6-phenyl, pyridin-2, -3 and -4-yl-5-azacytosines was prepared by their alkylation with diisopropyl (2-chloroethoxy)methylphosphonate followed by the deprotection. No antitumor or antiviral activity was found except for 6-(pyridin-4-yl)-1,3,5-triazine-2,4-diamine (13d) which exhibited slight activity against feline herpesvirus in CrFK cell cultures with IC50 = 6.7 mu g/mL.