N-(2-吡啶基)环丙烷甲酰胺 | 14372-23-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(2-吡啶基)环丙烷甲酰胺
• 中文别名: 乙醛，(8-喹啉基氧基)-(9CI)
• 英文名称: cyclopropanecarboxylic acid pyridin-2-ylamide
• 英文别名: N-(2-Pyridyl)-cyclopropancarboxamid；N-pyridin-2-ylcyclopropanecarboxamide
• CAS: 14372-23-7
• 化学式: C₉H₁₀N₂O
• mdl: MFCD01346045
• 分子量: 162.191
• InChiKey: NRFZSVJUQKNSNB-UHFFFAOYSA-N

物化性质

• 熔点：
  24-25 °C
• 沸点：
  387.2±15.0 °C(Predicted)
• 密度：
  1.296±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF<br/>[FR] DÉRIVÉS HÉTÉROCYCLIQUES FUSIONNÉS ET LEUR UTILISATION
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2009136663A1

  公开（公告）日：2009-11-12

  The present invention provides a fused heterocyclic derivative having a strong kinase inhibitory activity and use thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.

  本发明提供了一种具有强烈激酶抑制活性的融合杂环衍生物及其用途。本发明涉及本说明书中所定义的符号表示的化合物，或其盐。
• Fungicidal pyridyl cyclopropane carboximides
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0243972A2

  公开（公告）日：1987-11-04

  Novel fungicidal pyridyl cyclopropane carboxamides having the general structural formula wherein Z is R is selected from the group consisting of cycloalkyl, preferably cyclopropyl, hydrogen, alkyl, haloalkyl, substituted alkyl, aryl, substituted aryl, heteroalkyl, alkenyl, OR1, SR, and wherein n is 0-10, preferably 0-2, ad R1 is C1-C4 alkyl; R2 is selected from the group consisting of halogen such as chlorine, fluorine and bromine, preferably chlorine, C1-C3 alkoxy such as propoxy ethoxy and methoxy, preferably methoxy and C1-C3 haloalkoxy; R3 is selected from the group consisting of hydrogen and methyl; X is oxygen or sulfur and Y is oxygen or sulfur; or Z is SR9 wherein R9 is selected from the group consisting of haloalkyl, preferably C1-C3 haloalkyl, C1-C8 alkyl, aryl, substituted aryl, and arylalkyl wherein the preferred aryl is phenyl, the alkyl is C1-C3 alkyl and the preferred substitutions are Cl, Br, F and nitro, alkanoyl, preferably C1-C4 alkanoyl, wherein R4 and R5 can be alkyl, alkanoyl, alkoxycarbonyl, benzyl, pyridyl and substituted pyridyl; provided that when Z is -SR9 Y is oxygen; and fungicidally acceptable organic and inorganic salts thereof which are highly effective fungicides for use both as preventive and curative fungicides are disclosed herein.

  具有通式结构的新型吡啶基环丙烷羧酰胺类杀菌剂 其中 Z 是 R选自由环烷基（最好是环丙基）、氢、烷基、卤代烷基、取代烷基、芳基、取代芳基、杂烷基、烯基、OR1、SR组成的组；以及 其中 n 为 0-10，优选 0-2，R1 为 C1-C4 烷基；R2 选自氯、氟和溴等卤素（优选氯）、丙氧基乙氧基和甲氧基等 C1-C3 烷氧基（优选甲氧基）以及 C1-C3 卤代烷氧基组成的组；R3 选自氢和甲基组成的组；X 是氧或硫，Y 是氧或硫；或 Z 是 SR9，其中 R9 选自由卤代烷基（优选 C1-C3 卤代烷基）、C1-C8 烷基、芳基、取代的芳基和芳烷基组成的组，其中优选的芳基是苯基，烷基是 C1-C3 烷基，优选的取代基是 Cl、Br、F 和硝基、烷酰基（优选 C1-C4 烷酰基）、 其中 R4 和 R5 可以是烷基、烷酰基、烷氧羰基、苄基、吡啶基和取代的吡啶基；但当 Z 为 -SR9 时，Y 为氧；本文公开了其杀真菌可接受的有机盐和无机盐，它们是高效的杀真菌剂，既可用作预防性杀真菌剂，也可用作治疗性杀真菌剂。
• Fungicidal pyridyl cyclopropane carboxamides
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0243971A2

  公开（公告）日：1987-11-04

  Novel fungicidal pyridyl cyclopropane carboxamides having the general structural formula in which R is selected from the group halogen C1-C3 alkoxy and C1-C3 haloalkoxy, R, is selected from the group of-H and -C≡N; and R2 is selected from the group of-H, 1-CH3; and 2-CH3; X is O or S; and fungicidally acceptable organic and inorganic salts thereof. These compounds provide excellent control of fungal growth.

  新型杀菌剂吡啶基环丙烷羧酰胺，其结构通式为 其中 R 选自卤素 C1-C3 烷氧基和 C1-C3 卤代烷氧基组；R 选自-H 和-C≡N 组；R2 选自-H、1-CH3 和 2-CH3 组；X 为 O 或 S；以及杀真菌可接受的有机盐和无机盐。这些化合物能很好地控制真菌生长。
• Fungicidal n-pyridyl - haloamides
  申请人：ICI AMERICAS INC.

  公开号：EP0314428A2

  公开（公告）日：1989-05-03

  Novel fungicidal pyridyl cyclopropane carboxamides having the general structural formula wherein R is selected from the group consisting of C₁-C₃ alkoxy, C₁-C₃ haloalkoxy and halogen; and R₁ is C₁-C₆ haloalkyl; and fungicidally acceptable organic and inorganic salts thereof.

  新型杀菌剂吡啶基环丙烷羧酰胺，其结构通式为 其中 R 选自 C₁-C₃烷氧基、C₁-C₃卤代烷氧基和卤素组成的组；R₁ 是 C₁-C₆ 卤代烷基；以及它们的杀真菌可接受的有机盐和无机盐。
• Fungicidal pyridyl amides
  申请人：ICI AMERICAS INC.

  公开号：EP0314427A2

  公开（公告）日：1989-05-03

  Novel fungicidal pyridyl amides carboxamides having the general structural formula wherein R is selected from the group consisting of C₃-C₆ cycloalkyl, C₁-C₄ alkyl, benzyl, substituted benzyl wherein the substitutions are selected from the group of C₁-C₄ alkyl, C₁-C₄ alkoxy, C₁-C₄ alkanoyl, halogen, -NO₃ and C≡N, C₂-C₁₀ alkoxyalkyl, C₁-C₄ haloalkyl, C₂-C₈ alkenyl and alkanoyl; R₁ is selected from the group consisting of halogen such as chlorine, fluorine and bromine, C₁-C₃ alkoxy such as propoxyethoxy and methoxy, preferably methoxy and C₁-C₃ haloalkoxy; R₂ is selected from the group consisting of cyclopropyl, C₁-C₆ alkyl, C₁-C₆ alkoxy, C₂-C₆ alkoxyalkoxy, C₁-C₆ alkylthio, benzyl, substituted benzyl wherein the substitutions are selected from the group of C₁-C₄ alkyl, C₁-C₄ alkoxy, C₁-C₄ alkanoyl, halogen, -NO₃ and C≡N, and arylalkylthio; and X is -O or -S; and fungicidally acceptable organic and inorganic salts thereof which are highly effective fungicides for use both as preventive and curative fungi­cides are disclosed herein.

  新型杀菌剂吡啶酰胺羧酰胺，其结构通式为 其中 R选自由C₃-C₆环烷基、C₁-C₄烷基、苄基、取代的苄基组成的组，其中取代的苄基选自由C₁-C₄烷基组成的组、C₁-C₄ 烷氧基、C₁-C₄ 烷酰基、卤素、-NO₃ 和 C≡N、C₂-C₁₀ 烷氧基烷基、C₁-C₄ 卤代烷基、C₂-C₈ 烯基和烷酰基； R₁ 选自由卤素（如氯、氟和溴）、C₁-C₃ 烷氧基（如丙氧基乙氧基和甲氧基，优选甲氧基）和 C₁-C₃ 卤代烷氧基组成的组； R₂ 选自由环丙基、C₁-C₆ 烷基、C₁-C₆ 烷氧基、C₂-C₆ 烷氧基烷氧基、C₁-C₆ 烷硫基、苄基组成的组、取代的苄基，其中取代基选自 C₁-C₄ 烷基、C₁-C₄ 烷氧基、C₁-C₄ 烷酰基、卤素、-NO₃ 和 C≡N 以及芳烷基硫代物；和 X 是-O 或-S；以及 本文公开了其杀真菌可接受的有机盐和无机盐，它们是高效的杀真菌剂，既可用作预防性杀真菌剂，也可用作治疗性杀真菌剂。