5-ethoxymethyl-furan-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 5-ethoxymethyl-furan-2-carboxylic acid
• 英文别名: 5-Aethoxymethyl-furan-2-carbonsaeure；5-(ethoxymethyl)furan-2-carboxylic Acid
• 化学式: C₈H₁₀O₄
• mdl: MFCD04355935
• 分子量: 170.165
• InChiKey: WIVYCKXKKLJCNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.375
• 拓扑面积：
  59.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-ethoxymethyl-furan-2-carboxylic acid 在 氯化亚砜 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and Biological Evaluation of β-Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP)

  摘要：

  DOI：

  10.1021/acsmedchemlett.3c00515
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 5-ethoxymethyl-furan-2-carboxylic acid
  参考文献：
  名称：

  Middendorp, Recueil des Travaux Chimiques des Pays-Bas, 1919, vol. 38, p. 42

  摘要：

  DOI：

文献信息

• FURAN-2,5-DICARBOXYLIC ACID PURGE PROCESS
  申请人：EASTMAN CHEMICAL COMPANY

  公开号：US20190337914A1

  公开（公告）日：2019-11-07

  Disclosed is an oxidation process to produce a crude carboxylic acid product carboxylic acid product. The process comprises oxidizing a feed stream comprising at least one oxidizable compound to generate a crude carboxylic acid slurry comprising furan-2,5-dicarboxylic acid (FDCA) and compositions thereof. Also disclosed is a process to produce a dry purified carboxylic acid product by utilizing various purification methods on the crude carboxylic acid.

  本发明揭示了一种氧化过程，用于生产粗羧酸产品。该过程包括氧化至少一种可氧化化合物的进料流，以产生一种含有呋喃-2,5-二羧酸（FDCA）及其组分的粗羧酸淤泥。本发明还揭示了一种通过利用各种纯化方法对粗羧酸进行纯化，以生产干燥纯化羧酸产品的方法。
• Cooper; Nuttall, Journal of the Chemical Society, 1911, vol. 99, p. 1198
  作者：Cooper、Nuttall

  DOI：——

  日期：——
• Fischer,E.; v. Neyman, Chemische Berichte, 1914, vol. 47, p. 974
  作者：Fischer,E.、v. Neyman

  DOI：——

  日期：——
• AN OXIDATION PROCESS TO PRODUCE 5-(ALKOXYCARBONYL)FURAN-2-CARBOXYLIC ACIDS(ACFC)
  申请人：Eastman Chemical Company

  公开号：EP3810584A1

  公开（公告）日：2021-04-28
• PROCESS FOR PURIFYING CRUDE FURAN 2,5-DICARBOXYLIC ACID USING HYDROGENATION
  申请人：Eastman Chemical Company

  公开号：US20140235880A1

  公开（公告）日：2014-08-21

  A process to produce a dry purified furan-2,5-dicarboxylic acid (FDCA) is described. After oxidation of 5-(hydroxymethyl)furfural (5-HMF), a crude FDCA stream is produced that is fed to a crystallization zone followed by a solid-liquid displacement zone to form a low impurity slurry stream. The solids in the low impurity slurry stream are dissolved in a dissolution zone to produce a hydrogenation feed that is hydrogenated in a hydrogenation reactor to generate a hydrogenated FDCA composition. The hydrogenated FDCA composition is routed to a crystallization zone to form a crystallized produce stream that is separated from liquid in a solid-liquid separation zone to generate a purified wet cake stream containing FDCA that can be dried in a drying zone to generate a dry purified FDCA product stream.