3-Amino-6-hydroxy-4-methyl-thieno[2,3-b]pyridine-2-carboxylic acid amide | 128918-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 3-Amino-6-hydroxy-4-methyl-thieno[2,3-b]pyridine-2-carboxylic acid amide
• 英文别名: 3-amino-4-methyl-6-oxo-7H-thieno[2,3-b]pyridine-2-carboxamide
• CAS: 128918-09-2
• 化学式: C₉H₉N₃O₂S
• 分子量: 223.255
• InChiKey: XFOCPDNNQGEGBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Sodium; 3-amino-2-carbamoyl-4-methyl-thieno[2,3-b]pyridin-6-olate 在 盐酸 作用下， 以 水 为溶剂， 生成 3-Amino-6-hydroxy-4-methyl-thieno[2,3-b]pyridine-2-carboxylic acid amide
  参考文献：
  名称：

  Wagner; Vieweg; Leistner, Pharmazie, 1990, vol. 45, # 2, p. 102 - 109

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AS IKK INHIBITORS<br/>[FR] COMPOSES AMIDE D'ACIDE 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXYLIQUE SUBSTITUE SERVANT D'INHIBITEURS D'IKK
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2005056562A1

  公开（公告）日：2005-06-23

  Disclosed are compounds of formula (I): wherein the variables R1, R2, R3 and Z are described herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  披露了公式(I)的化合物：其中变量R1、R2、R3和Z如本文所述，它们作为IκB激酶(IKK)复合物的激酶活性的抑制剂是有用的。因此，这些化合物在治疗IKK介导的疾病，包括自身免疫性疾病、炎症性疾病和癌症方面是有用的。还披露了包含这些化合物的药物组合物以及制备这些化合物的方法。
• [EN] SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES<br/>[FR] COMPOSES AMIDE D'ACIDE 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIQUE SUBSTITUES ET PROCESSUS DE PREPARATION ET D'UTILISATION DE CES COMPOSES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2003103661A1

  公开（公告）日：2003-12-18

  Disclosed are compounds of formula (I), wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  公开的是式(I)的化合物，其中R1和R2如本文所定义，这些化合物可用作IκB激酶（IKK）复合物激酶活性的抑制剂。因此，这些化合物在治疗IKK介导的疾病，包括自身免疫疾病、炎症性疾病和癌症方面是有用的。还公开了包含这些化合物的药物组合物以及制备这些化合物的方法。
• Quaternary ammonium compounds
  申请人：——

  公开号：US20030158176A1

  公开（公告）日：2003-08-21

  Novel quaternary ammonium compounds of the formula 1 and any stereoisomers thereof, wherein R 1 , R 2 and R 3 independently represent C 1 -C 6 alkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R 1 , R 2 and R 3 may form a ring together with the quaternary ammonium nitrogen; R 4 represents —H, —CH 3 , or —CO—R 4-1 ,wherein R 4-1 represents —(C 1 -C 4 alkyl), —(C 1 -C 4 alkoxy), or —NR 4-2 R 4-3 , wherein R 4-2 and R 4-3 independently represent —H or —(C 1 -C 4 alkyl); R 5 , R 6 and R 7 independently represent —H, —OCH 3 , —OH, —CONH 2 , —SO 2 NH 2 , —F, —Cl, —Br, —I, —CF 3 , or —(C 1 -C 4 alkyl), optionally substituted with one or two —OH, —(C 1 -C 4 alkoxy), —COOH, or —CO—O—(C 1 -C 3 alkyl); and X − represents an anion of a pharmaceutically acceptable acid, the compounds for use as medicaments, use of the compounds for the manufacture of specific medicaments, and pharmaceutical compositions comprising the compounds. The present invention also concerns a method of treatment involving administration of the compounds.

  新颖的四元铵化合物的化学式为1，及其所有立体异构体，其中R1、R2和R3分别表示C1-C6烷基，可选择地取代为苯基或羟基，或两者兼有，且其中任意两个R1、R2和R3可与四元铵氮形成环；R4表示—H，—CH3，或—CO—R4-1，其中R4-1表示—(C1-C4烷基)，—(C1-C4烷氧基)，或—NR4-2R4-3，其中R4-2和R4-3独立地表示—H或—(C1-C4烷基)；R5、R6和R7独立地表示—H，—O ，—OH，—CONH2，—SO2NH2，—F，—Cl，—Br，—I，—CF3，或—(C1-C4烷基)，可选择地取代为一个或两个—OH，—(C1-C4烷氧基)，—COOH，或—CO—O—(C1-C3烷基)；X-表示药学上可接受的酸的阴离子，这些化合物用作药物，用这些化合物制造特定药物的用途，以及包含这些化合物的药物组合物。本发明还涉及涉及给药的治疗方法。
• SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES
  申请人：GINN David John

  公开号：US20070293533A1

  公开（公告）日：2007-12-20

  Disclosed are compounds of formula (I): wherein R 1 and R 4 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases, cardiovascular disease and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  公开了以下化合物的结构（I）：其中R1和R4如本文所定义，这些化合物可用作IκB激酶（IKK）复合物的激酶活性抑制剂。因此，这些化合物在治疗IKK介导的疾病中具有用途，包括自身免疫性疾病、炎症性疾病、心血管疾病和癌症。还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
• Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
  申请人：Cywin L. Charles

  公开号：US20050288285A1

  公开（公告）日：2005-12-29

  Disclosed are compounds of formula (I): wherein R 1 and R 2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  本发明涉及化合物(I)的公开，其中R1和R2在此定义，这些化合物可用作IκB激酶（IKK）复合物的激酶活性抑制剂。因此，这些化合物可用于治疗由IKK介导的疾病，包括自身免疫性疾病、炎症性疾病和癌症。还公开了包含这些化合物的药物组合物和制备这些化合物的过程。