4-(5,5,8,8-Tetramethyl-1-oxo-1,3,5,6,7,8-hexahydro-benzo[f]isoindol-2-yl)-benzoic acid | 121866-09-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 4-(5,5,8,8-Tetramethyl-1-oxo-1,3,5,6,7,8-hexahydro-benzo[f]isoindol-2-yl)-benzoic acid
• 英文别名: 4-(5,5,8,8-tetramethyl-3-oxo-6,7-dihydro-1H-benzo[f]isoindol-2-yl)benzoic acid
• CAS: 121866-09-9
• 化学式: C₂₃H₂₅NO₃
• 分子量: 363.456
• InChiKey: ZFGHCUQSWCSJJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl (3-bromomethyl)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthoate 以 甲醇 为溶剂， 反应 48.0h， 生成 4-(5,5,8,8-Tetramethyl-1-oxo-1,3,5,6,7,8-hexahydro-benzo[f]isoindol-2-yl)-benzoic acid
  参考文献：
  名称：

  Retinobenzoic acids. 4. Conformation of aromatic amides with retinoidal activity. Importance of trans-amide structure for the activity

  摘要：

  N-Methylation of two retinoidal amide compounds, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benz oic acid (3, Am80) and 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2- naphthalenyl)carbonyl]amino]benzoic acid (5, Am580), resulted in the disappearance of their potent differentiation-inducing activity on human promyelocytic leukemia cell line HL-60. Studies with 1H NMR and UV spectroscopy indicated that large conformational differences exist between the active secondary amides and the inactive N-methyl amides. From a comparison of the spectroscopic results of these amides with those of stilbene derivatives, the conformations of the active amides are expected to resemble that of (E)-stilbene, whereas the inactive amides resemble the Z isomer: 3 (Am80) and 5 (Am580) have a trans-amide bond and their whole structures are elongated, while the N-methylated compounds [4 (Am90) and 6 (Am590)] have a cis-amide bond, resulting in the folding of the two benzene rings. These structures in the crystals were related to those in solution by 13C NMR spectroscopic comparison between the two phases (solid and solution).

  DOI：

  10.1021/jm00130a011

文献信息

• Retinobenzoic acids. 4. Conformation of aromatic amides with retinoidal activity. Importance of trans-amide structure for the activity
  作者：Hiroyuki Kagechika、Toshiyuki Himi、Emiko Kawachi、Koichi Shudo

  DOI：10.1021/jm00130a011

  日期：1989.10

  N-Methylation of two retinoidal amide compounds, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benz oic acid (3, Am80) and 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2- naphthalenyl)carbonyl]amino]benzoic acid (5, Am580), resulted in the disappearance of their potent differentiation-inducing activity on human promyelocytic leukemia cell line HL-60. Studies with 1H NMR and UV spectroscopy indicated that large conformational differences exist between the active secondary amides and the inactive N-methyl amides. From a comparison of the spectroscopic results of these amides with those of stilbene derivatives, the conformations of the active amides are expected to resemble that of (E)-stilbene, whereas the inactive amides resemble the Z isomer: 3 (Am80) and 5 (Am580) have a trans-amide bond and their whole structures are elongated, while the N-methylated compounds [4 (Am90) and 6 (Am590)] have a cis-amide bond, resulting in the folding of the two benzene rings. These structures in the crystals were related to those in solution by 13C NMR spectroscopic comparison between the two phases (solid and solution).