2-methyl-benzothiazole; perchlorate | 74162-74-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-methyl-benzothiazole; perchlorate
• 英文别名: 2-Methyl-benzothiazol; Perchlorat；2-Methylbenzothiazolium perchlorate；2-methyl-1,3-benzothiazol-3-ium;perchlorate
• CAS: 74162-74-6
• 化学式: C₈H₇NS*ClHO₄
• 分子量: 249.675
• InChiKey: SUEXBLUCOBVZTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.52
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  117
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-methyl-benzothiazole; perchlorate 、 环氧氯丙烷 在 2-甲基苯并噻唑 作用下， 反应 0.25h， 以70%的产率得到3-(3-chloro-2-hydroxypropyl)-2-methylbenzothiazolium perchlorate
  参考文献：
  名称：

  N-杂环与环氧丙烷和环氧氯丙烷的季铵化

  摘要：

  摘要 在高氯酸或氢溴酸存在下，环氧丙烷和环氧氯丙烷与适当的杂环碱反应，制备了几种新型重要的杂环 N-2-羟丙基和 N-2-羟基-3-氯丙基季盐，得到无色纯化合物。副产品。反应产物在 2 位或 4 位具有活化的甲基，是典型的前体，适用于合成不同类型的花青染料。所有产品均通过 1H-NMR 光谱和元素分析进行​​表征。

  DOI：

  10.1081/scc-200025601

文献信息

• Loaded latex optical molecular imaging probes
  申请人：Leon Jeffrey W.

  公开号：US20080181965A1

  公开（公告）日：2008-07-31

  The present invention relates to a loaded latex particle comprising a latex material made from a mixture represented by formula (X)m-(Y)n-(Z)o-(W)p, wherein Y is at least one monomer with at least two ethylenically unsaturated chemical functionalities; Z is at least one polyethylene glycol macromonomer with an average molecular weight of between 300 and 10,000; W is an ethylenic monomer different from X, Y, or Z; and X is at least one water insoluble, alkoxethyl containing monomer; and m, n, o, and p are the respective weight percentages of each monomer. The particle may be loaded with a fluorescent dye.

  本发明涉及一种载荷乳胶颗粒，该乳胶材料由以下式表示的混合物制成：(X)m-(Y)n-(Z)o-(W)p，其中Y至少是一种具有至少两个乙烯不饱和化学官能团的单体；Z至少是一种聚乙二醇马克蒙单体，其平均分子量在300至10,000之间；W是与X、Y或Z不同的乙烯单体；X至少是一种水不溶性、含有烷氧基乙烯的单体；m、n、o和p分别是每种单体的重量百分比。该颗粒可以装载荧光染料。
• CHUJGUK V. A., UKR. XIM. ZH., 1980, 46, HO 4, 389-390
  作者：CHUJGUK V. A.

  DOI：——

  日期：——
• LOADED LATEX OPTICAL MOLECULAR IMAGING PROBES
  申请人：Carestream Health, Inc.

  公开号：EP2004713B1

  公开（公告）日：2011-03-09
• FLUORESCENCE RESONANCE ENERGY TRANSFER DETECTION WITH NANOPARTICLES FOR IN VITRO AND IN VIVO APPLICATIONS
  申请人：Papineni Rao

  公开号：US20090061532A1

  公开（公告）日：2009-03-05

  A combination of nanoparticles is disclosed comprised of amine functionalized polyethylene glycol in which one particle with a fluorescent donor dye having one wavelength excitation maximum and at least one additional particle with a second fluorescent dye having a second, higher wavelength excitation maximum, the particles having the same or different biomolecule targeting moieties bound to their external surfaces.
• Molecular imaging probes based on loaded reactive nano-scale latex
  申请人：Li Guizhi

  公开号：US20100034748A1

  公开（公告）日：2010-02-11

  The present invention relates to a loaded reactive nanoscale latex particle synthesized from mixture of monomers containing water insoluble monomers, at least two ethylenically functionalities monomers, halo-aromatic-polyethyleneglycol-methacrylate, polyethyleneglycolacrylate containing macromonomers, and up to 10 wt % other ethylenic monomers different from above monomers. The reactive halo-aromatic groups on the surface of latex particle are servable as linkers to react with peptides, antibodies, nucleic acids, ligands or other biomolecules.