(3R)-oxane-3-carbohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (3R)-oxane-3-carbohydrazide
• 化学式: C₆H₁₂N₂O₂
• 分子量: 144.17
• InChiKey: OBOQJPQGKZQKEM-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• HETEROCYCLIC TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR
  申请人：AMGEN INC.

  公开号：US20170320860A1

  公开（公告）日：2017-11-09

  Compounds of Formula I and Formula II, pharmaceutically acceptable salts thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

  公式I和公式II的化合物，其药用盐，上述任何一个的立体异构体，或它们的混合物是APJ受体的激动剂，可能用于治疗心血管和其他疾病。公式I和公式II的化合物具有以下结构： 其中变量的定义在此提供。
• Compounds for use in preparing heterocyclic triazole agonists of the APJ receptor
  申请人：AMGEN INC.

  公开号：US10150760B2

  公开（公告）日：2018-12-11

  Compounds of Formula V, salts thereof, tautomers thereof, and salts of the tautomers have the following structure and are useful compounds in preparing small molecule agonists of the APJ Receptor: where the definitions of the variables are provided herein.

  式 V 的化合物、其盐、同系物和同系物的盐具有如下结构，是制备 APJ 受体小分子激动剂的有用化合物： 其中变量的定义见本文。
• Pyrazolopyrimidinone compounds and uses thereof
  申请人：Aduro BioTech, Inc.

  公开号：US10738056B2

  公开（公告）日：2020-08-11

  The present invention relates to pyrazolopyrimidinone compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating autoimmune, inflammatory, and neurodegenerative diseases by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及吡唑嘧啶酮化合物。本发明还涉及含有这些化合物的药物组合物，以及通过向有需要的受试者施用这些化合物和药物组合物来治疗自身免疫性、炎症性和神经退行性疾病的方法。本发明还涉及将这些化合物用于研究或其他非治疗目的。
• COMPOUNDS FOR USE IN PREPARING HETEROCYCLIC TRIAZOLE AGONISTS OF THE APJ RECEPTOR
  申请人：AMGEN INC.

  公开号：US20180222895A1

  公开（公告）日：2018-08-09

  Compounds of Formula V, salts thereof, tautomers thereof, and salts of the tautomers have the following structure and are useful compounds in preparing small molecule agonists of the APJ Receptor: where the definitions of the variables are provided herein.
• PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF
  申请人：Aduro BioTech, Inc.

  公开号：US20190119285A1

  公开（公告）日：2019-04-25

  The present invention relates to pyrazolopyrimidinone compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating autoimmune, inflammatory, and neurodegenerative diseases by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.