(2S)-3-(6-aminopurin-9-yl)-2-methoxypropan-1-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (2S)-3-(6-aminopurin-9-yl)-2-methoxypropan-1-ol
• 化学式: C₉H₁₃N₅O₂
• 分子量: 223.23
• InChiKey: JBTYCAYQBLWDEV-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  99.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS
  申请人：ALIGOS THERAPEUTICS, INC.

  公开号：US20200147124A1

  公开（公告）日：2020-05-14

  Various embodiments provide STOPS™ polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS™ modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS™ modified oligonucleotides, as determined by HBsAg Secretion Assay, is greater than that of a reference compound.