9-[(2S)-2,3-dimethoxypropyl]purin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-[(2S)-2,3-dimethoxypropyl]purin-6-amine
• 化学式: C₁₀H₁₅N₅O₂
• 分子量: 237.26
• InChiKey: LKJGJYJCYBQOKU-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  88.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• S-antigen transport inhibiting oligonucleotide polymers and methods
  申请人：ALIGOS THERAPEUTICS, INC.

  公开号：US11166976B2

  公开（公告）日：2021-11-09

  Various embodiments provide STOPS™ polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS™ modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS™ modified oligonucleotides, as determined by HBsAg Secretion Assay, is greater than that of a reference compound.

  各种实施方案提供了抑制 S 抗原转运的寡核苷酸聚合物 STOPS™、其制造工艺以及用其治疗疾病和病症的方法。在某些实施方案中，STOPS™修饰的寡核苷酸包括至少部分硫代磷酸序列，该序列由具有本文所述修饰的交替 A 和 C 单元组成。通过 HBsAg 分泌测定法确定，STOPS™ 修饰寡核苷酸实施例的序列独立乙型肝炎抗病毒活性高于参比化合物。
• S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS
  申请人：ALIGOS THERAPEUTICS, INC.

  公开号：US20200405743A1

  公开（公告）日：2020-12-31

  Various embodiments provide STOPS™ polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS™ modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS™ modified oligonucleotides, as determined by HBsAg Secretion Assay, is greater than that of a reference compound.