24,25-dihydroxycycloartan-3-one | 883312-00-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 24,25-dihydroxycycloartan-3-one
• 英文别名: (1S,3R,8R,11S,12S,15R,16R)-15-[(2R)-5,6-dihydroxy-6-methylheptan-2-yl]-7,7,12,16-tetramethylpentacyclo[9.7.0.01,3.03,8.012,16]octadecan-6-one
• CAS: 883312-00-3
• 化学式: C₃₀H₅₀O₃
• 分子量: 458.725
• InChiKey: JCGYBQRUVSZLCH-DSDGCTLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  24,25-dihydroxycycloartan-3-one 、 乙酸酐 在 吡啶 作用下， 反应 0.03h， 以15 mg的产率得到24ξ,25-diacetoxy-9β,19-cyclo-lanostan-3-one
  参考文献：
  名称：

  Jayakumar; Ajithabai; Santhosh, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 2, p. 429 - 431

  摘要：

  DOI：
• 作为产物：
  描述：

  Acetic acid (R)-1-(1-hydroxy-1-methyl-ethyl)-4-((5R,8S,9S,10R,13R,14S,17R)-4,4,13,14-tetramethyl-3-oxo-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthren-17-yl)-pentyl ester 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 0.02h， 以86%的产率得到24,25-dihydroxycycloartan-3-one
  参考文献：
  名称：

  Jayakumar; Ajithabai; Santhosh, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 2, p. 429 - 431

  摘要：

  DOI：

文献信息

• 発癌予防剤及びシクロアルタン型トリテルペン系化合物の製造方法
  申请人：学校法人日本大学

  公开号：JP2006131595A

  公开（公告）日：2006-05-25

  【課題】 安全で有効な発癌予防剤を提供する。【解決手段】 本発明の発癌予防剤は、２４−メチルシクロアルタン−３β，２４，２４1−トリオール、２４1−メトキシ−２４−メチルシクロアルタン−３β，２４−ジオール、シクロアルタン−３，２４−ジオン、４，４，１４−トリメチル−９，１９−シクロプレグナン−３，２０−ジオン、２４，２５−ジヒドロキシシクロアルタン−３−オン、２５−ヒドロキシシクロアルト−２３−エン−３−オン、２５−ヒドロキシ−２４−メトキシシクロアルタン−３−オンからなる群から選ばれた少なくとも１種のシクロアルタン型トリテルペン系化合物を含有する。【選択図】図１

  提供一种安全有效的致癌物预防剂。本发明的致癌物预防剂是 24-甲基环木菠萝烷-3β,24,241-三醇、241-甲氧基-24241-甲氧基-24-甲基环木菠萝烷-3β,24-二醇、环木菠萝烷-3,24-二酮、4,4,14-三甲-9,19-cyclopregnane-3,20-dione, 24,25-dihydroxycycloartan-3-烯-3-酮、25-羟基环木菠萝烷-23-烯-3-酮、25-羟基-24甲氧基环木菠萝烷-3-酮组成的组中选出的至少一种环木菠萝烷类三萜化合物。[选图] 图 1.
• Biotransformation of Cycloartane-Type Triterpenes by the Fungus <i>Glomerella </i><i>f</i><i>usarioides</i>
  作者：Toshihiro Akihisa、Kenji Watanabe、Risa Yoneima、Takashi Suzuki、Yumiko Kimura

  DOI：10.1021/np058120d

  日期：2006.4.1

  Biotransformation of three cycloartane-type triterpenes, cycloartenol (1), 24-methylenecycloartanol (2), and cycloartenone (3), by the fungus Glomerella fusarioides was studied. Compound 1 was converted to 3, cycloart-25-ene-3 beta, 24-diol (4), and cycloartane-3 beta, 24,25-triol (5). Compound 2 was metabolized to cycloeucalenol (6) and two new compounds, 24-methylcycloartane-3 beta,24,24(1)-triol (7) and 24(1)-methoxy-24-methylcycloartane-3 beta, 24-diol (8). Compound 3 was converted into two new metabolites, 4 alpha,4 beta,14 alpha-trimethyl-9 beta, 19-cyclopregnane-3,20-dione (9) and 25-hydroxy-24-methoxycycloartan-3-one (14), and four known compounds, viz., cycloartane-3,24-dione (10), 24-hydroxycycloart-25-en-3-one (11), (23E)-25-hydroxycycloart-23-en-3-one (12), and 24,25-dihydroxycycloartan-3-one (13). The structures of four new metabolites, 7, 8, 9, and 14, were established by spectroscopic methods.
• Nath; Chakraborty, Journal of the Indian Chemical Society, 1945, vol. 22, p. 19,20
  作者：Nath、Chakraborty

  DOI：——

  日期：——
• METHODS FOR INHIBITING PROSTATE CANCER BY KINASES AND ANGIOGENESIS INHIBITORY MECHANISMS OF BALL MOSS EXTRACT
  申请人：Lowe Henry

  公开号：US20150004260A1

  公开（公告）日：2015-01-01

  A method of treating prostate cancer by administering a pharmaceutically-acceptable amount of a crude extract of the indigenous Jamaican plant Ball Moss ( Tillandsia Recurvata ) comprising one or more cycloartane isolates, and the isolates used in the method for eliciting thereby a kinase inhibitory response of prostate cancer cells by selectively inhibiting MRCKα kinase and angiogenesis of (growth of new blood vessels) to reduce the viability of prostate cancer cells. The method and compounds holds promise as a chemopreventive agent, without causing excessive damage to normal cells.
• Jayakumar; Ajithabai; Santhosh, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 2, p. 429 - 431
  作者：Jayakumar、Ajithabai、Santhosh、Veena、Nairt, Mangalam S.

  DOI：——

  日期：——