3-(2-hydroxy-ethyl)-tetrahydro-pyran-4-ol | 693245-86-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 3-(2-hydroxy-ethyl)-tetrahydro-pyran-4-ol
• 英文别名: 3-(2-Hydroxy-aethyl)-tetrahydro-pyran-4-ol；1,5-Anhydro-2,4-dideoxy-2-(2-hydroxyethyl)pentitol；3-(2-hydroxyethyl)oxan-4-ol
• CAS: 693245-86-2
• 化学式: C₇H₁₄O₃
• 分子量: 146.186
• InChiKey: WRZJPWXLXKCGDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-hydroxy-ethyl)-tetrahydro-pyran-4-ol 、 2-硝基苯基丝氰酸酯 在 三丁基膦 作用下， 生成
  参考文献：
  名称：

  Design, synthesis, and structure–activity relationship of novel CCR2 antagonists

  摘要：

  A series of novel 1-aminocyclopentyl-3-carboxyamides incorporating substituted tetrahydropyran moieties have been synthesized and subsequently evaluated for their antagonistic activity against the human CCR2 receptor. Among them analog 59 was found to posses potent antagonistic activity. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2008.12.050
• 作为产物：
  描述：

  2-allyltetrahydropyranone 在 臭氧 、 sodium tetrahydroborate 作用下， 以 二氯甲烷 为溶剂， 生成 3-(2-hydroxy-ethyl)-tetrahydro-pyran-4-ol
  参考文献：
  名称：

  Design, synthesis, and structure–activity relationship of novel CCR2 antagonists

  摘要：

  A series of novel 1-aminocyclopentyl-3-carboxyamides incorporating substituted tetrahydropyran moieties have been synthesized and subsequently evaluated for their antagonistic activity against the human CCR2 receptor. Among them analog 59 was found to posses potent antagonistic activity. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2008.12.050

文献信息

• Olsen; Brandal, Acta Chemica Scandinavica (1947), 1954, vol. 8, p. 420,423
  作者：Olsen、Brandal

  DOI：——

  日期：——
• US7390803B2
  申请人：——

  公开号：US7390803B2

  公开（公告）日：2008-06-24