4-isopropyl-7-hexyltropolone | 650594-15-3

• 分子结构分类: 有机化合物 - 碳氢化合物衍生物 - 环庚三烯酮
• 英文名称: 4-isopropyl-7-hexyltropolone
• 英文别名: 2,4,6-Cycloheptatrien-1-one, 7-hexyl-2-hydroxy-4-(1-methylethyl)-；3-hexyl-2-hydroxy-6-propan-2-ylcyclohepta-2,4,6-trien-1-one
• CAS: 650594-15-3
• 化学式: C₁₆H₂₄O₂
• 分子量: 248.365
• InChiKey: SPTQSQIFTWXYGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-isopropyl-7-hydroxyhexyltropolone 在 磷化氢 、 水 、 碘 、 溶剂黄146 、 potassium carbonate 作用下， 以 水 、 溶剂黄146 为溶剂， 反应 1.0h， 生成 4-isopropyl-7-hexyltropolone
  参考文献：
  名称：

  Substituted tropolone compounds, oral care compositions containing the same and methods of using the same

  摘要：

  本发明涉及本发明的新型环己酮化合物以及适用于预防或治疗温血动物包括人类口腔疾病或状况的口腔护理组合物，包括口腔护理有效量的至少一种新型环己酮化合物和药用可接受的口腔载体。本发明还涉及一种方法，通过将口腔护理组合物的口腔护理有效量应用于口腔，预防或治疗温血动物包括人类口腔疾病或状况。

  公开号：

  US20040018216A1

文献信息

• ORAL CARE COMPOSITIONS COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS AND METHODS OF USING THE SAME
  申请人：——

  公开号：US20040018154A1

  公开（公告）日：2004-01-29

  The present invention relates to oral care compositions suitable for preventing or treating diseases or conditions of the oral cavity in warm-blooded animals including humans, comprising an oral care effective amount of at least one tropolone compound in combination with at least one essential oil, and a pharmaceutically acceptable oral carrier. This invention further relates to a method for preventing or treating diseases or conditions of the oral cavity in warm-blooded animals including humans, by applying an oral care effective amount of the oral care composition to the oral cavity.

  本发明涉及适用于预防或治疗温血动物，包括人类口腔腔内疾病或病症的口腔护理组合物，包括至少一种茚三酮化合物和至少一种精油的口腔护理有效量，以及药学上可接受的口腔载体。本发明还涉及一种方法，通过将口腔护理组合物的口腔护理有效量应用于口腔，预防或治疗温血动物，包括人类口腔腔内疾病或病症。
• Oral care compositions comprising tropolone compounds and essential oils and methods of using the same
  申请人：——

  公开号：US20040185010A1

  公开（公告）日：2004-09-23

  The present invention relates to oral care compositions suitable for preventing or treating diseases or conditions of the oral cavity in warm-blooded animals including humans, comprising an oral care effective amount of at least one tropolone compound in combination with at least one essential oil, and a pharmaceutically acceptable oral carrier. This invention further relates to a method for preventing or treating diseases or conditions of the oral cavity in warm-blooded animals including humans, by applying an oral care effective amount of the oral care composition to the oral cavity.

  本发明涉及适用于预防或治疗包括人类在内的温血动物口腔疾病或病症的口腔护理组合物，该组合物包含口腔护理有效量的至少一种tropolone化合物与至少一种精油，以及药学上可接受的口腔载体。本发明进一步涉及一种预防或治疗包括人类在内的温血动物口腔疾病或病症的方法，方法是将口腔护理有效量的口腔护理组合物涂抹于口腔。
• ORAL CARE COMPOSITION COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS
  申请人：Warner-Lambert Company LLC

  公开号：EP1536759A1

  公开（公告）日：2005-06-08
• Oral Care Compositions Comprising Tropolone Compounds and Essential Oils and Methods of Using The Same
  申请人：Pan Pauline

  公开号：US20090081134A1

  公开（公告）日：2009-03-26

  The present invention relates to oral care compositions suitable for preventing or treating diseases or conditions of the oral cavity in warm-blooded animals including humans, comprising an oral care effective amount of at least one tropolone compound in combination with at least one essential oil, and a pharmaceutically acceptable oral carrier. This invention further relates to a method for preventing or treating diseases or conditions of the oral cavity in warm-blooded animals including humans, by applying an oral care effective amount of the oral care composition to the oral cavity.
• US6689342B1
  申请人：——

  公开号：US6689342B1

  公开（公告）日：2004-02-10