5-chloro-3-isobutyl-3H-imidazo[4,5-b]pyridin-2-amine | 1587697-74-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 5-chloro-3-isobutyl-3H-imidazo[4,5-b]pyridin-2-amine
• 英文别名: 5-Chloro-3-isobutyl-3H-imidazo[4,5-b]pyridin-2-ylamine；5-chloro-3-(2-methylpropyl)imidazo[4,5-b]pyridin-2-amine
• CAS: 1587697-74-2
• 化学式: C₁₀H₁₃ClN₄
• 分子量: 224.693
• InChiKey: GJLOYOQSWRHFGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  56.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-chloro-N2-isobutylpyridine-2,3-diamine 在 盐酸 、 三氯氧磷 作用下， 以 乙醇 、 水 、 乙腈 为溶剂， 反应 5.5h， 生成 5-chloro-3-isobutyl-3H-imidazo[4,5-b]pyridin-2-amine
  参考文献：
  名称：

  Preparation of 2-Aminopyridoimidazoles and 2-Aminobenzimidazoles via Phosphorus Oxychloride-Mediated Cyclization of Aminoureas

  摘要：

  The novel preparation of 2-aminopyridoimidazoles and 2-aminobenzimidazoles via the cyclization of (2-aminopyridin-3-yl)urea and (2-aminophenyl)urea substrates in the presence of phosphorus oxychloride is described. This methodology is demonstrated for a range of urea substrates with aminoimidazole products obtained in good yields and with excellent levels of purity.

  DOI：

  10.1021/jo500360k

文献信息

• IMIDAZO(4,5-B) PYRIDIN-2-YL AMIDES AS KV7 CHANNEL ACTIVATORS
  申请人：KNOPP BIOSCIENCES LLC

  公开号：US20160031875A1

  公开（公告）日：2016-02-04

  Compounds represented by formula 1 can be potent and/or partially selective for the Kv7.2/7.3 heteromultimer. They may be useful in treating disorders related to seizures, pain, neurotransmitter release, etc.

  由公式1表示的化合物可能对Kv7.2/7.3异源多聚体具有强效和/或部分选择性。它们可能在治疗与癫痫、疼痛、神经递质释放等相关的疾病方面有用。
• Imidazo(4,5-B) pyridin-2-yl amides as KV7 channel activators
  申请人：Knopp Biosciences LLC

  公开号：US10106536B2

  公开（公告）日：2018-10-23

  Compounds represented by formula 1 can be potent and/or partially selective for the Kv7.2/7.3 heteromultimer. They may be useful in treating disorders related to seizures, pain, neurotransmitter release, etc.

  式 1 所代表的化合物对 Kv7.2/7.3 异源二聚体具有强效和/或部分选择性。它们可用于治疗与癫痫发作、疼痛、神经递质释放等有关的疾病。
• IMIDAZO[4,5-B]PYRIDIN-2-YL AMIDES AS KV7 CHANNEL ACTIVATORS
  申请人：Knopp Biosciences LLC

  公开号：US20190002464A1

  公开（公告）日：2019-01-03

  Compounds represented by formula 1 can be potent and/or partially selective for the Kv7.2/7.3 heteromultimer. They may be useful in treating disorders related to seizures, pain, neurotransmitter release, etc.
• US9650376B2
  申请人：——

  公开号：US9650376B2

  公开（公告）日：2017-05-16
• [EN] IMIDAZO(4,5-B) PYRIDIN-2-YL AMIDES AS KV7 CHANNEL ACTIVATORS<br/>[FR] IMIDAZO(4,5-B) PYRIDINE-2-YL AMIDES EN TANT QUE D'ACTIVATEURS DU CANAL KV7
  申请人：KNOPP BIOSCIENCES LLC

  公开号：WO2014145852A2

  公开（公告）日：2014-09-18

  Compounds represented by formula 1 can be potent and/or partially selective for the Kv7.2/7.3 heteromultimer. They may be useful in treating disorders related to seizures, pain, neurotransmitter release, etc.