dimethyl 2-(4-fluorophenyl)-5-(trifluoromethyl)furan-3,4-dicarboxylate | 1333158-69-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: dimethyl 2-(4-fluorophenyl)-5-(trifluoromethyl)furan-3,4-dicarboxylate
• 英文别名: 2-(Trifluoromethyl)-5-(4-fluorophenyl)furan-3,4-dicarboxylic acid dimethyl ester
• CAS: 1333158-69-2
• 化学式: C₁₅H₁₀F₄O₅
• 分子量: 346.235
• InChiKey: XUOZAPHSIRTCLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  65.7
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  dimethyl (2E)-2-(4-fluorobenzoyl)but-2-enedioate 、 三氟乙酸酐 在 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 以99%的产率得到dimethyl 2-(4-fluorophenyl)-5-(trifluoromethyl)furan-3,4-dicarboxylate
  参考文献：
  名称：

  A Powerful Cascade Approach for Expeditious Synthesis of Trifluoromethylated Furans

  摘要：

  A powerful approach to synthesize trifluoromethylated furans has been developed. The method is operationally simple, broad in substrate scope, and amenable to scale-up using trifluoroacetic anhydride. Meanwhile, the strategy not only provided a versatile approach to synthesize trifluoromethylated furans but also provides a new method for exploring the new reactivity of trifluoroacetic anhydride.

  DOI：

  10.1021/ol2022092

文献信息

• A Powerful Cascade Approach for Expeditious Synthesis of Trifluoromethylated Furans
  作者：Yao Wang、Yong-Chun Luo、Xiu-Qin Hu、Peng-Fei Xu

  DOI：10.1021/ol2022092

  日期：2011.10.7

  A powerful approach to synthesize trifluoromethylated furans has been developed. The method is operationally simple, broad in substrate scope, and amenable to scale-up using trifluoroacetic anhydride. Meanwhile, the strategy not only provided a versatile approach to synthesize trifluoromethylated furans but also provides a new method for exploring the new reactivity of trifluoroacetic anhydride.