γ-cholesterol-L-glutamate | 53648-18-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: γ-cholesterol-L-glutamate
• 英文别名: (2S)-2-amino-5-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-5-oxopentanoic acid
• CAS: 53648-18-3
• 化学式: C₃₂H₅₃NO₄
• 分子量: 515.777
• InChiKey: CJTCOGCISXNIBJ-CRIAFXJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  三光气 、 γ-cholesterol-L-glutamate 以 四氢呋喃 为溶剂， 以37.8%的产率得到γ-cholesterol-L-glutamate-N-carboxyanhydride
  参考文献：
  名称：

  Biocompatible poly(ethylene glycol)-poly(γ-cholesterol-L-glutamate) copolymers: Synthesis, characterization, andin vitrostudies

  摘要：

  AbstractA novel amphiphilic poly(ethylene glycol)‐block‐poly(γ‐cholesterol‐L‐glutamate) (mPEG–PCHLG) diblock copolymer has been synthesized. The mPEG–PCHLG copolymer has good biocompatibility and low toxicity. The mPEG–PCHLG copolymers could aggregate into nanoparticles with PCHLG blocks as the hydrophobic core and PEG blocks as the hydrophilic shell through emulsion solvent evaporation method. The copolymers were characterized by nuclear magnetic resonance spectroscopy, mass spectrum, Fourier transform infrared spectroscopy, and gel permeation chromatography. The particle sizes, size distributions, and zeta potentials of nanoparticles can also be determined by dynamic light scattering and transmission electron microscopy. This work provides a new and facile approach to prepare amphiphilic block copolymer nanoparticles with controllable performances. This novel copolymer may have potential applications in drug delivery and bioimaging applications.© 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012

  DOI：

  10.1002/pola.26265
• 作为产物：
  描述：

  N-Boc-γ-cholesterol-L-glutamate-α-tert-butyl ester 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以10.3 g的产率得到γ-cholesterol-L-glutamate
  参考文献：
  名称：

  Biocompatible poly(ethylene glycol)-poly(γ-cholesterol-L-glutamate) copolymers: Synthesis, characterization, andin vitrostudies

  摘要：

  AbstractA novel amphiphilic poly(ethylene glycol)‐block‐poly(γ‐cholesterol‐L‐glutamate) (mPEG–PCHLG) diblock copolymer has been synthesized. The mPEG–PCHLG copolymer has good biocompatibility and low toxicity. The mPEG–PCHLG copolymers could aggregate into nanoparticles with PCHLG blocks as the hydrophobic core and PEG blocks as the hydrophilic shell through emulsion solvent evaporation method. The copolymers were characterized by nuclear magnetic resonance spectroscopy, mass spectrum, Fourier transform infrared spectroscopy, and gel permeation chromatography. The particle sizes, size distributions, and zeta potentials of nanoparticles can also be determined by dynamic light scattering and transmission electron microscopy. This work provides a new and facile approach to prepare amphiphilic block copolymer nanoparticles with controllable performances. This novel copolymer may have potential applications in drug delivery and bioimaging applications.© 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012

  DOI：

  10.1002/pola.26265